1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid phenyl amide

Base Information

Chemical Name:1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid phenyl amide
CAS No.:1401447-86-6
Molecular Formula:C₂₃H₃₁N₃OSi
Molecular Weight:393.604
Hs Code.:

Synonyms:1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid phenyl amide

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Chemical Property of 1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid phenyl amide

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Technology Process of 1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid phenyl amide

There total 3 articles about 1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid phenyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.9%

: 13154-24-0
triisopropylsilyl chloride

: 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid phenyl amide

: 1401447-86-6
1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid phenyl amide

Guidance literature:: 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid phenyl amide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h;

triisopropylsilyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; for 12h;

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1401447-86-6
1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid phenyl amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; (diphenylphosphin)ferrocene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 18 h / 120 °C

2.1: sodium hydroxide / ethanol; water / 16 h / 70 - 80 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.2: 5 h / 80 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

4.2: 12 h / 20 °C

With (diphenylphosphin)ferrocene; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 344327-11-3
1H-pyrrolo[2,3-b]pyridine-4-carbonitrile

: 1401447-86-6
1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid phenyl amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol; water / 16 h / 70 - 80 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.2: 5 h / 80 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

3.2: 12 h / 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;