(E)-tert-butyl 2-((2-(3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamido)ethyl)disulfanyl)ethylcarbamate

Base Information

• Chemical Name: (E)-tert-butyl 2-((2-(3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamido)ethyl)disulfanyl)ethylcarbamate
• CAS No.: 1383447-50-4
• Molecular Formula: C₁₈H₂₆BrN₃O₅S₂
• Molecular Weight: 508.458
• Mol file: 1383447-50-4.mol

Synonyms:(E)-tert-butyl 2-((2-(3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamido)ethyl)disulfanyl)ethylcarbamate

Chemical Property of (E)-tert-butyl 2-((2-(3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamido)ethyl)disulfanyl)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-tert-butyl 2-((2-(3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamido)ethyl)disulfanyl)ethylcarbamate

There total 3 articles about (E)-tert-butyl 2-((2-(3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamido)ethyl)disulfanyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

(E)-3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanoic acid (146884-05-1) + N-tert-butoxycarbonyl cystamine (485800-26-8) → (E)-tert-butyl 2-((2-(3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamido)ethyl)disulfanyl)ethylcarbamate (1383447-50-4)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol; at 20 ℃; for 12h;

Reference yield: 28.0%

3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanoic acid (862269-71-4) + N-tert-butoxycarbonyl cystamine (485800-26-8) → (E)-tert-butyl 2-((2-(3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamido)ethyl)disulfanyl)ethylcarbamate (1383447-50-4)

Guidance literature:

3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanoic acid; With 1-hydroxy-pyrrolidine-2,5-dione; In N,N-dimethyl-formamide; for 0.0833333h; Inert atmosphere;

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

N-tert-butoxycarbonyl cystamine; In N,N-dimethyl-formamide; at 20 - 30 ℃; for 111h; Inert atmosphere;

DOI:10.1039/c2ob25909e

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (E)-tert-butyl 2-((2-(3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamido)ethyl)disulfanyl)ethylcarbamate (1383447-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / methanol / 20 °C

2: dicyclohexyl-carbodiimide; triethylamine; 1-hydroxy-pyrrolidine-2,5-dione / 1,4-dioxane; methanol / 12 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol;

upstream raw materials:

3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanoic acid

N-tert-butoxycarbonyl cystamine

(E)-3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanoic acid

di-tert-butyl dicarbonate