(1R,2S)-1--2-<<<(methylthio)(toluenesulfonylimino)methyl>amino>methyl>cyclopropane-1-carboxylic acid

Base Information

Chemical Name:(1R,2S)-1--2-<<<(methylthio)(toluenesulfonylimino)methyl>amino>methyl>cyclopropane-1-carboxylic acid
CAS No.:154704-12-8
Molecular Formula:C₁₉H₂₇N₃O₆S₂
Molecular Weight:457.572
Hs Code.:

(1R,2S)-1-<N-(tert-Butoxycarbonyl)amino>-2-<<<(methylthio)(toluenesulfonylimino)methyl>amino>methyl>cyclopropane-1-carboxylic acid

Synonyms:(1R,2S)-1--2-<<<(methylthio)(toluenesulfonylimino)methyl>amino>methyl>cyclopropane-1-carboxylic acid

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Chemical Property of (1R,2S)-1--2-<<<(methylthio)(toluenesulfonylimino)methyl>amino>methyl>cyclopropane-1-carboxylic acid

Chemical Property:

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Technology Process of (1R,2S)-1--2-<<<(methylthio)(toluenesulfonylimino)methyl>amino>methyl>cyclopropane-1-carboxylic acid

There total 8 articles about (1R,2S)-1--2-<<<(methylthio)(toluenesulfonylimino)methyl>amino>methyl>cyclopropane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154704-20-8
(1S,2R)-(+)-2-(Benzyloxymethyl)-1-(ethoxycarbonyl)cyclopropane-1-carboxylic acid

: 154704-12-8
(1R,2S)-1--2-<<<(methylthio)(toluenesulfonylimino)methyl>amino>methyl>cyclopropane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: NEt₃, N₃PO(OPh)2 / 12 h / Heating

2: H₂ / 10percent Pd/C / ethyl acetate / 48 h / 25 °C

3: NEt₃ / CH₂Cl₂ / 10 h / 25 °C

4: NaN₃ / dimethylformamide / 18 h / 40 °C

5: 1 M aq. NaOH / ethanol / 30 h / 25 °C

6: H₂ / 10percent Pd/C / methanol; H₂O / 4 h / 25 °C

7: 2 N aq. NaOH / ethanol / 12 h / 60 °C

With sodium hydroxide; sodium azide; diphenyl phosphoryl azide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00087a039

Reference yield:

: 154704-11-7
(1R,2S)-(Azidomethyl)-1-cyclopropane-1-carboxylic acid

: 154704-12-8
(1R,2S)-1--2-<<<(methylthio)(toluenesulfonylimino)methyl>amino>methyl>cyclopropane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol; H₂O / 4 h / 25 °C

2: 2 N aq. NaOH / ethanol / 12 h / 60 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; ethanol; water;
DOI:10.1021/jo00087a039

Reference yield:

: 154704-09-3
(R)-(-)-Diethyl 2-(benzyloxymethyl)cyclopropane-1,1-dicarboxylate

: 154704-12-8
(1R,2S)-1--2-<<<(methylthio)(toluenesulfonylimino)methyl>amino>methyl>cyclopropane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: Na₂CO₃ / aq. ethanol / 48 h / 60 °C

2: NEt₃, N₃PO(OPh)2 / 12 h / Heating

3: H₂ / 10percent Pd/C / ethyl acetate / 48 h / 25 °C

4: NEt₃ / CH₂Cl₂ / 10 h / 25 °C

5: NaN₃ / dimethylformamide / 18 h / 40 °C

6: 1 M aq. NaOH / ethanol / 30 h / 25 °C

7: H₂ / 10percent Pd/C / methanol; H₂O / 4 h / 25 °C

8: 2 N aq. NaOH / ethanol / 12 h / 60 °C

With sodium hydroxide; sodium azide; diphenyl phosphoryl azide; hydrogen; sodium carbonate; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00087a039