N-((S)-1-(1,1-dimethylethoxycarbonyl)-5-oxopyrrolidine-2-carbonyl)-L-valine pentafluorophenyl ester

Base Information

Chemical Name:N-((S)-1-(1,1-dimethylethoxycarbonyl)-5-oxopyrrolidine-2-carbonyl)-L-valine pentafluorophenyl ester
CAS No.:938075-92-4
Molecular Formula:C₂₁H₂₃F₅N₂O₆
Molecular Weight:494.415
Hs Code.:

Synonyms:N-((S)-1-(1,1-dimethylethoxycarbonyl)-5-oxopyrrolidine-2-carbonyl)-L-valine pentafluorophenyl ester

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Chemical Property of N-((S)-1-(1,1-dimethylethoxycarbonyl)-5-oxopyrrolidine-2-carbonyl)-L-valine pentafluorophenyl ester

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Technology Process of N-((S)-1-(1,1-dimethylethoxycarbonyl)-5-oxopyrrolidine-2-carbonyl)-L-valine pentafluorophenyl ester

There total 8 articles about N-((S)-1-(1,1-dimethylethoxycarbonyl)-5-oxopyrrolidine-2-carbonyl)-L-valine pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 938075-91-3
N-((S)-1-(1,1-dimethylethoxycarbonyl)-5-oxopyrrolidine-2-carbonyl)-L-valine

: 14533-84-7
pentafluorophenyl trifloroacetate

: 938075-92-4
N-((S)-1-(1,1-dimethylethoxycarbonyl)-5-oxopyrrolidine-2-carbonyl)-L-valine pentafluorophenyl ester

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; for 1h;
DOI:10.1016/j.bmc.2007.03.005

Reference yield:

: 938075-90-2
N-((S)-1-(1,1-dimethylethoxycarbonyl)-5-oxopyrrolidine-2-carbonyl)-L-valine phenylmethyl ester

: 938075-92-4
N-((S)-1-(1,1-dimethylethoxycarbonyl)-5-oxopyrrolidine-2-carbonyl)-L-valine pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd-C / methanol / 6 h

2: 83 percent / pyridine / dimethylformamide / 1 h

With pyridine; hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.03.005

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 938075-92-4
N-((S)-1-(1,1-dimethylethoxycarbonyl)-5-oxopyrrolidine-2-carbonyl)-L-valine pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 9.0 g / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 384 h / 20 °C

2: 93 percent / H₂ / Pd-C / methanol / 6 h

3: 71 percent / 1-hydroxybenzotriazole; N,N'-dicyclohexylcarbodiimide; ethyldiisopropylamine / CH₂Cl₂ / 24 h / 0 °C

4: 100 percent / H₂ / Pd-C / methanol / 6 h

5: 83 percent / pyridine / dimethylformamide / 1 h

With pyridine; dmap; hydrogen; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.03.005