(Z)-3-phenyl-2-trityloxycarbamoylacrylic acid ethyl ester

Base Information

• Chemical Name: (Z)-3-phenyl-2-trityloxycarbamoylacrylic acid ethyl ester
• CAS No.: 934619-01-9
• Molecular Formula: C₃₁H₂₇NO₄
• Molecular Weight: 477.56
• Mol file: 934619-01-9.mol

Synonyms:(Z)-3-phenyl-2-trityloxycarbamoylacrylic acid ethyl ester

Chemical Property of (Z)-3-phenyl-2-trityloxycarbamoylacrylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (Z)-3-phenyl-2-trityloxycarbamoylacrylic acid ethyl ester

There total 2 articles about (Z)-3-phenyl-2-trityloxycarbamoylacrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-tritylhydroxylamine (31938-11-1) + (E)-ethyl 2-(chlorocarbonyl)-3-phenylacrylate → (Z)-3-phenyl-2-trityloxycarbamoylacrylic acid ethyl ester (934619-01-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jm061169b

Reference yield:

2-[1-phenyl-(Z)-methylidene]malonic acid monoethyl ester (24302-10-1) → (Z)-3-phenyl-2-trityloxycarbamoylacrylic acid ethyl ester (934619-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / dimethylformamide / CH₂Cl₂ / 0.75 h / 0 °C

2: diisopropylethylamine / CH₂Cl₂ / 3 h / 20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm061169b

Reference yield: 85.0%

(Z)-3-phenyl-2-trityloxycarbamoylacrylic acid ethyl ester (934619-01-9) → (E)-3-phenyl-2-tritylcarbamoylacrylic acid

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1021/jm900648x

upstream raw materials:

O-tritylhydroxylamine

2-[1-phenyl-(Z)-methylidene]malonic acid monoethyl ester

Downstream raw materials:

(E)-3-phenyl-2-trityloxycarbamoylacrylic acid

2-benzylidene-N-(4-fluoro-benzyl)-N'-trityloxy-malonamide

2-benzylidene-N-(4-phenyl-butyl)-N'-trityloxy-malonamide