4-{2-[1-(3,4-dichlorobenzoyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}-N,N-dimethyl-benzamide

Base Information

Chemical Name:4-{2-[1-(3,4-dichlorobenzoyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}-N,N-dimethyl-benzamide
CAS No.:1200571-64-7
Molecular Formula:C₂₉H₂₈Cl₂N₂O₄
Molecular Weight:539.458
Hs Code.:

Synonyms:4-{2-[1-(3,4-dichlorobenzoyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}-N,N-dimethyl-benzamide

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Chemical Property of 4-{2-[1-(3,4-dichlorobenzoyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}-N,N-dimethyl-benzamide

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Technology Process of 4-{2-[1-(3,4-dichlorobenzoyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}-N,N-dimethyl-benzamide

There total 6 articles about 4-{2-[1-(3,4-dichlorobenzoyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}-N,N-dimethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1200575-57-0
N,N-dimethyl-4-(2-piperidin-4-yl-4H-1,3-benzodioxin-6-yl)benzamide

: 51-44-5
3,4-dichlorbenzoic acid

: 1200571-64-7
4-{2-[1-(3,4-dichlorobenzoyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}-N,N-dimethyl-benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran;

Reference yield:

: 2316-64-5
5-bromo-2-hydroxybenzyl alcohol

: 1200571-64-7
4-{2-[1-(3,4-dichlorobenzoyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}-N,N-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / chloroform / 12 h / Molecular sieve; Reflux

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 15 h / 90 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran

With potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water;

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 1200571-64-7
4-{2-[1-(3,4-dichlorobenzoyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}-N,N-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / chloroform / 3 h / Molecular sieve; Dean-Stark apparatus; Reflux

2: water; sodium hydroxide / methanol / 15 h / 90 °C / Sealed tube

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 15 h / 90 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran

With water; potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water;