5-chloro-2-{(E)-3-[3-(4-fluorobenzyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-4-methoxy-N,N-dimethyl-benzenesulfonamide

Base Information

Chemical Name:5-chloro-2-{(E)-3-[3-(4-fluorobenzyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-4-methoxy-N,N-dimethyl-benzenesulfonamide
CAS No.:868406-65-9
Molecular Formula:C₂₅H₂₉ClFN₃O₄S
Molecular Weight:522.04
Hs Code.:

Synonyms:5-chloro-2-{(E)-3-[3-(4-fluorobenzyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-4-methoxy-N,N-dimethyl-benzenesulfonamide

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Chemical Property of 5-chloro-2-{(E)-3-[3-(4-fluorobenzyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-4-methoxy-N,N-dimethyl-benzenesulfonamide

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Technology Process of 5-chloro-2-{(E)-3-[3-(4-fluorobenzyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-4-methoxy-N,N-dimethyl-benzenesulfonamide

There total 5 articles about 5-chloro-2-{(E)-3-[3-(4-fluorobenzyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-4-methoxy-N,N-dimethyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 417727-43-6
3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]octane

: C₁₂H₁₃Cl₂NO₄S

: 868406-65-9
5-chloro-2-{(E)-3-[3-(4-fluorobenzyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-4-methoxy-N,N-dimethyl-benzenesulfonamide

Guidance literature:: 3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]octane; C₁₂H₁₃Cl₂NO₄S; In dichloromethane; for 0.166667h;

With ammonia; In dichloromethane; water;

Reference yield:

: 868406-69-3
(E)-3-(4-chloro-2-dimethylsulfamoyl-5-methoxy-phenyl)-acrylic acid

: 868406-65-9
5-chloro-2-{(E)-3-[3-(4-fluorobenzyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-4-methoxy-N,N-dimethyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / xylene / 0.17 h / Heating / reflux

2: dichloromethane / 0.17 h

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; xylene;

Reference yield:

: 868406-68-2
(E)-3-(4-chloro-2-dimethylsulfamoyl-5-methoxy-phenyl)-acrylic acid ethyl ester

: 868406-65-9
5-chloro-2-{(E)-3-[3-(4-fluorobenzyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-4-methoxy-N,N-dimethyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; ethanol; water / 0.25 h / Heating / reflux

2: thionyl chloride / N,N-dimethyl-formamide / xylene / 0.17 h / Heating / reflux

3: dichloromethane / 0.17 h

With sodium hydroxide; thionyl chloride; ethanol; water; N,N-dimethyl-formamide; In dichloromethane; xylene;