3-[5-(2-fluoro-phenyl)-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyridazin-3-ylamide

Base Information

Chemical Name:3-[5-(2-fluoro-phenyl)-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyridazin-3-ylamide
CAS No.:1186234-39-8
Molecular Formula:C₁₉H₁₆FN₅O₂
Molecular Weight:365.367
Hs Code.:

Synonyms:3-[5-(2-fluoro-phenyl)-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyridazin-3-ylamide

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Chemical Property of 3-[5-(2-fluoro-phenyl)-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyridazin-3-ylamide

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Technology Process of 3-[5-(2-fluoro-phenyl)-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyridazin-3-ylamide

There total 4 articles about 3-[5-(2-fluoro-phenyl)-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyridazin-3-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1186234-56-9
3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid pyridazin-3-ylamide

: 1993-03-9
o-fluorophenylboronic acid

: 1186234-39-8
3-[5-(2-fluoro-phenyl)-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyridazin-3-ylamide

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; at 100 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 69045-79-0
2-choro-5-iodopyridine

: 1186234-39-8
3-[5-(2-fluoro-phenyl)-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyridazin-3-ylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

1.2: 70 °C / Inert atmosphere

2.1: dichloromethane / 18 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Cooling with ice; Inert atmosphere

3.2: 20 °C / Cooling with ice; Inert atmosphere

4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.5 h / 100 °C / Microwave irradiation; Inert atmosphere

With sodium hydride; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1186234-48-9
2-(1-benzhydryl-azetidin-3-yloxy)-5-iodo-pyridine

: 1186234-39-8
3-[5-(2-fluoro-phenyl)-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyridazin-3-ylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 18 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Cooling with ice; Inert atmosphere

2.2: 20 °C / Cooling with ice; Inert atmosphere

3.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.5 h / 100 °C / Microwave irradiation; Inert atmosphere

With sodium hydride; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;