(1-fluorocarbonylmethyl-2-methyl-propyl)-carbamic acid benzyl ester

Base Information

• Chemical Name: (1-fluorocarbonylmethyl-2-methyl-propyl)-carbamic acid benzyl ester
• CAS No.: 918964-87-1
• Molecular Formula: C₁₄H₁₈FNO₃
• Molecular Weight: 267.3
• Mol file: 918964-87-1.mol

Synonyms:(1-fluorocarbonylmethyl-2-methyl-propyl)-carbamic acid benzyl ester

Chemical Property of (1-fluorocarbonylmethyl-2-methyl-propyl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (1-fluorocarbonylmethyl-2-methyl-propyl)-carbamic acid benzyl ester

There total 1 articles about (1-fluorocarbonylmethyl-2-methyl-propyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-<(benzyoxycarbonyl)amino>-4-methylpentanoic acid (215608-32-5) → (1-fluorocarbonylmethyl-2-methyl-propyl)-carbamic acid benzyl ester (918964-87-1)

Guidance literature:

With pyridine; trifluoro-[1,3,5]triazine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1002/anie.200602167

Reference yield: 93.0%

(1-fluorocarbonylmethyl-2-methyl-propyl)-carbamic acid benzyl ester (918964-87-1) + 3-[3-(2-aminomethyl-3-methyl-butyrylamino)-butyrylamino]-4-phenyl-butyric acid 4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl)-benzyl ester; compound with trifluoro-acetic acid → 3-(3-{2-[(3-benzyloxycarbonylamino-4-methyl-pentanoylamino)-methyl]-3-methyl-butyrylamino}-butyrylamino)-4-phenyl-butyric acid 4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl)-benzyl ester

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/anie.200602167

Reference yield:

(1-fluorocarbonylmethyl-2-methyl-propyl)-carbamic acid benzyl ester (918964-87-1) → 3-(3-{2-[(3-amino-4-methyl-pentanoylamino)-methyl]-3-methyl-butyrylamino}-butyrylamino)-4-phenyl-butyric acid

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / dimethylformamide / 0.03 h / 120 °C

2: H₂ / Pd/C / ethyl acetate; 2-methyl-propan-2-ol; H₂O / 2.5 h / atmospheric pressure

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1002/anie.200602167

upstream raw materials:

(R)-3-<(benzyoxycarbonyl)amino>-4-methylpentanoic acid

Downstream raw materials:

3-(3-{2-[(3-benzyloxycarbonylamino-4-methyl-pentanoylamino)-methyl]-3-methyl-butyrylamino}-butyrylamino)-4-phenyl-butyric acid benzyl ester