Technology Process of (2R,4S,5S,6S,7S)-7-((4-methoxybenzyl)oxy)-4,6,8-trimethyl-3-oxo-5-((triethylsilyl)oxy)nonan-2-yl benzoate
There total 6 articles about (2R,4S,5S,6S,7S)-7-((4-methoxybenzyl)oxy)-4,6,8-trimethyl-3-oxo-5-((triethylsilyl)oxy)nonan-2-yl benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine;
In
dichloromethane;
at -78 - 0 ℃;
for 0.833333h;
Inert atmosphere;
DOI:10.1002/anie.201109080
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: dicyclohexylboron chloride; triethylamine / diethyl ether / 2.25 h / -78 - 0 °C / Inert atmosphere
2.2: 17 h / -17 °C / Inert atmosphere
3.1: 2,6-dimethylpyridine / dichloromethane / 0.83 h / -78 - 0 °C / Inert atmosphere
With
2,6-dimethylpyridine; oxalyl dichloride; dicyclohexylboron chloride; dimethyl sulfoxide; triethylamine;
In
diethyl ether; dichloromethane;
1.1: Swern oxidation / 1.2: Swern oxidation;
DOI:10.1002/anie.201109080
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / 17 h / 20 °C / 1.2 Torr / Inert atmosphere
2.1: diisobutylaluminium hydride / dichloromethane; toluene / 3.33 h / -20 - -10 °C / Inert atmosphere
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
4.1: dicyclohexylboron chloride; triethylamine / diethyl ether / 2.25 h / -78 - 0 °C / Inert atmosphere
4.2: 17 h / -17 °C / Inert atmosphere
5.1: 2,6-dimethylpyridine / dichloromethane / 0.83 h / -78 - 0 °C / Inert atmosphere
With
2,6-dimethylpyridine; oxalyl dichloride; dicyclohexylboron chloride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
diethyl ether; dichloromethane; toluene;
3.1: Swern oxidation / 3.2: Swern oxidation;
DOI:10.1002/anie.201109080
