C₃₃H₄₃FN₄O₉

Base Information

• Chemical Name: C₃₃H₄₃FN₄O₉
• CAS No.: 1264241-85-1
• Molecular Formula: C₃₃H₄₃FN₄O₉
• Molecular Weight: 658.724
• Mol file: 1264241-85-1.mol

Synonyms:C₃₃H₄₃FN₄O₉

Chemical Property of C₃₃H₄₃FN₄O₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₄₃FN₄O₉

There total 19 articles about C₃₃H₄₃FN₄O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C40H51FN4O11 (1264241-81-7) → C33H43FN4O9 (1264241-85-1)

Guidance literature:

With 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; ethyl acetate;

Reference yield:

C34H42FN3O10 (1264241-77-1) → C33H43FN4O9 (1264241-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C

2: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; ethyl acetate / 20 °C

With 1-hydroxy-7-aza-benzotriazole; 1,3-dimethylbarbituric acid; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

C30H38FN3O8 (1264241-74-8) → C33H43FN4O9 (1264241-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / 1,4-dioxane; water / 15 h / 0 - 20 °C

2: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C

3: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; ethyl acetate / 20 °C

With 1-hydroxy-7-aza-benzotriazole; 1,3-dimethylbarbituric acid; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

C₃₀H₃₈FN₃O₈

C₄₀H₅₁FN₄O₁₁

C₃₄H₄₂FN₃O₁₀

C₃₇H₄₆FN₃O₁₀

Refernces

• 1、 -. "Conformation-constrained entirely-synthetic macrocyclic compounds". . . Retrieved 2016/10/07.
• 2、 -. "CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS". . . Retrieved 2012/08/27.