β-benzylthiopropionyl-tyrosyl-D-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine

Base Information

Chemical Name:β-benzylthiopropionyl-tyrosyl-D-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine
CAS No.:86965-60-8
Molecular Formula:C₄₇H₅₅N₇O₁₀S₂
Molecular Weight:942.127
Hs Code.:

Synonyms:β-benzylthiopropionyl-tyrosyl-D-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of β-benzylthiopropionyl-tyrosyl-D-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine

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Technology Process of β-benzylthiopropionyl-tyrosyl-D-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine

There total 5 articles about β-benzylthiopropionyl-tyrosyl-D-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 86965-59-5
β-benzylthiopropionyl-tyrosyl-D-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine benzyl ester

: 86965-60-8
β-benzylthiopropionyl-tyrosyl-D-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine

Guidance literature:: With hydrogen bromide; In acetic acid; at 60 ℃; for 0.25h;
DOI:10.1135/cccc19831341

Reference yield:

: 21685-51-8
D-phenylalanine methyl ester

: 86965-60-8
β-benzylthiopropionyl-tyrosyl-D-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) butyl nitrite, 6.4 M-HCl, 2.) N-methylmorpholine / 1.) dioxane, DMF, -20 deg C, 15 min, 2.) 0 deg C, 15 h; R_.T_. 5 h.

2: 93 percent / 1M NaOH / H₂O / 0.67 h

3: 89 percent / N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / dimethylformamide / 1.) 0 deg C, 2 h, 2.) 25 deg C, overnight.

4: 61 percent / 35 percent hydrogen bromide / acetic acid / 0.25 h / 60 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; n-Butyl nitrite; hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1135/cccc19831341

Reference yield:

: 3481-43-4
β-benzylthiopropionyl-tyrosine hydrazide

: 86965-60-8
β-benzylthiopropionyl-tyrosyl-D-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) butyl nitrite, 6.4 M-HCl, 2.) N-methylmorpholine / 1.) dioxane, DMF, -20 deg C, 15 min, 2.) 0 deg C, 15 h; R_.T_. 5 h.

2: 93 percent / 1M NaOH / H₂O / 0.67 h

3: 89 percent / N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / dimethylformamide / 1.) 0 deg C, 2 h, 2.) 25 deg C, overnight.

4: 61 percent / 35 percent hydrogen bromide / acetic acid / 0.25 h / 60 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; n-Butyl nitrite; hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1135/cccc19831341