Technology Process of (3R,4S,5R)-3,4-Diacetoxy-5-hydroxy-cyclohex-1-enecarboxylic acid methyl ester
There total 10 articles about (3R,4S,5R)-3,4-Diacetoxy-5-hydroxy-cyclohex-1-enecarboxylic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) H2O, AcOH; 2.) N,N-dimethylolpyridine / 1.) methanol, toluene, r.t., 1 h; 2) ether, 1 h
2: 80 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / 5 °C
With
N,N-dimethylolpyridine; tetrabutyl ammonium fluoride; water; acetic acid;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / p-toluenesulfonic acid, Na2CO3 / CH2Cl2 / 5 °C
2: imidazole / dimethylformamide / 1.75 h
3: 1.) H2O, AcOH; 2.) N,N-dimethylolpyridine / 1.) methanol, toluene, r.t., 1 h; 2) ether, 1 h
4: 80 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / 5 °C
With
1H-imidazole; N,N-dimethylolpyridine; tetrabutyl ammonium fluoride; water; sodium carbonate; toluene-4-sulfonic acid; acetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;