10-Methoxyibogamine

Base Information Edit

Chemical Name:10-Methoxyibogamine
CAS No.:83-74-9
Molecular Formula:C20H26N2O
Molecular Weight:310.439
Hs Code.:
European Community (EC) Number:201-498-4
Wikipedia:Ibogaine
Wikidata:Q105033042
Metabolomics Workbench ID:69134
ChEMBL ID:CHEMBL222287
Mol file:83-74-9.mol

Synonyms:12 Methoxyibogamine;12-Methoxyibogamine;Endabuse;Ibogaine;NIH 10567;NIH-10567;NIH10567

Suppliers and Price of 10-Methoxyibogamine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Arctom
Ibogaine ≥98%
5mg
$ 293.00

American Custom Chemicals Corporation
IBOGAINE 95.00%
5MG
$ 503.92

Total 74 raw suppliers

Chemical Property of 10-Methoxyibogamine Edit

Chemical Property:

Vapor Pressure:1.57E-09mmHg at 25°C
Melting Point:152-153°
Refractive Index:1.643
Boiling Point:484.2 °C at 760 mmHg
PKA:8.1 in 80% methylcellosolve
Flash Point:246.6 °C
PSA：28.26000
Density:1.2 g/cm³
LogP:3.87450
Storage Temp.:2-8°C
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:310.204513457
Heavy Atom Count:23
Complexity:455

Purity/Quality:

99%, ^*data from raw suppliers

Ibogaine ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,T
Hazard Codes:F,T
Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1CC2CC3C1N(C2)CCC4=C3NC5=C4C=C(C=C5)OC
Isomeric SMILES:CC[C@H]1C[C@H]2C[C@@H]3[C@H]1N(C2)CCC4=C3NC5=C4C=C(C=C5)OC
Recent EU Clinical Trials:The Efficacy of Ibogaine in the Treatment of Addiction; an open label, single fixed dose pilot-study of the efficacy of ibogaine in opioid-dependent subjects
Description This indole alkaloid occurs in the root of Tabernanthe iboga Baill. It was first examined in detail by Raymond-Hamet who assigned to it the empirical formula C19H24(26)ON2, now altered to that given above. The base forms colourless crystals from EtOH and is laevorotatory with [Q1D - 53° (EtOH). It is insoluble in Et20, slightly so in Me2CO or CHC1 3 but dissolves freely in MeOH, EtOH or H20. The alkaloid yields a hydrochloride, m.p. 299°C (dec.); lQlhs - 67° (MeOH) or - 37.3° (H20). It contains one methoxyl group and gives the typical indole reactions. On distillation with Zn dust or soda-lime it furnishes products which are indole derivatives with the ~-position free. In a manner similar to that of cocaine, the alkaloid potentiates the pressor action of adrenaline and abolishes the sino-carotid reflexes. Unlike cocaine, however, it also augments the action of tyramine and that of dl-ephedrine to a slight extent. Vincent and Sero have reported that it inhibits the action of serum cholinesterase.

Technology Process of 10-Methoxyibogamine

There total 13 articles about 10-Methoxyibogamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.15%

: ibogaine hydrochloride

: 83-74-9
ibogaine

Guidance literature:: With potassium carbonate; In dichloromethane; for 0.166667h; Inert atmosphere;

Reference yield: 86.0%

: 510-22-5
voacangine

: 83-74-9
ibogaine

Guidance literature:: voacangine; With potassium hydroxide; In ethanol; Reflux;

With hydrogenchloride; In water; at 0 ℃; for 0.0833333h; pH=1; Reflux;
DOI:10.1021/acschemneuro.0c00152