N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolin-iodid

Base Information

• Chemical Name: N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolin-iodid
• CAS No.: 86040-73-5
• Molecular Formula: C₂₆H₃₄N₂O₅P*I
• Molecular Weight: 612.445
• Mol file: 86040-73-5.mol

Synonyms:N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolin-iodid

Chemical Property of N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolin-iodid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolin-iodid

There total 4 articles about N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolin-iodid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolin-tert-butylester-iodid (86040-72-4) → N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolin-iodid (86040-73-5)

Guidance literature:

With trifluoroacetic acid; at 0 ℃; for 1h;

DOI:10.1002/jlac.198319830302

Reference yield:

N-(2-Bromethoxycarbonyl)valin (61445-18-9) → N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolin-iodid (86040-73-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / oxalylchloride / CH₂Cl₂ / 2 h

2: 83 percent / triethylamine / CH₂Cl₂ / 15 h / 0 °C

3: 1) NaI / 1) acetone, 15 h, reflux, 2) 4 d, reflux

4: 76 percent / trifluoroacetic acid / 1 h / 0 °C

With Chloro-oxo-acetic acid; triethylamine; trifluoroacetic acid; sodium iodide; In dichloromethane;

DOI:10.1002/jlac.198319830302

Reference yield:

N-(2-Bromethoxycarbonyl)valylchlorid (86050-08-0) → N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolin-iodid (86040-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / triethylamine / CH₂Cl₂ / 15 h / 0 °C

2: 1) NaI / 1) acetone, 15 h, reflux, 2) 4 d, reflux

3: 76 percent / trifluoroacetic acid / 1 h / 0 °C

With triethylamine; trifluoroacetic acid; sodium iodide; In dichloromethane;

DOI:10.1002/jlac.198319830302

upstream raw materials:

N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolin-tert-butylester-iodid

N-(2-Bromethoxycarbonyl)valin

N-(2-Bromethoxycarbonyl)valylchlorid

N-(2-Bromethoxycarbonyl)valyl-prolin-tert-butylester

Downstream raw materials:

N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolyl-isoleucin-tert-butylester-iodid

N-<2-(Methyldiphenylphosphonio)ethoxycarbonyl>valyl-prolyl-isoleucin-iodid