2,3-dihydro-4,7-dimethoxy-1H-inden-2-amine

Base Information

• Chemical Name: 2,3-dihydro-4,7-dimethoxy-1H-inden-2-amine
• CAS No.: 79381-08-1
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 79381-08-1.mol

Synonyms:2,3-dihydro-4,7-dimethoxy-1H-inden-2-amine

Chemical Property of 2,3-dihydro-4,7-dimethoxy-1H-inden-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dihydro-4,7-dimethoxy-1H-inden-2-amine

There total 1 articles about 2,3-dihydro-4,7-dimethoxy-1H-inden-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,7-dimethoxyindan-1-one (52428-09-8) → 2,3-dihydro-4,7-dimethoxy-1H-inden-2-amine (79381-08-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 78 percent / NaH / bis-(2-methoxy-ethyl) ether; benzene / 17 h / Ambient temperature

2: H₂, 70percent perchloric acid / 10percent Pd/C / acetic acid / 2 h / 2587.7 Torr

3: 48 percent / KOH, H₂O / ethanol / 5 h / Ambient temperature

4: 1.) Et₃N, ethyl chloroformate, 2.) sodium azide / 1.) acetone, H₂O, 0 deg C, 30 min, 2.) acetone, H₂O, 0 deg C, 90 min

5: toluene / 1 h / Heating

6: 20percent aq. HCl / 2 h / Heating

With hydrogenchloride; potassium hydroxide; sodium azide; perchloric acid; water; hydrogen; chloroformic acid ethyl ester; sodium hydride; triethylamine; palladium on activated charcoal; In ethanol; diethylene glycol dimethyl ether; acetic acid; toluene; benzene;

DOI:10.1021/jm00349a019

Reference yield:

(R)-5-(2-oxiranyl)-8-benzyloxy-2(1H)-quinolinone (173140-90-4) + 2,3-dihydro-4,7-dimethoxy-1H-inden-2-amine (79381-08-1) → (R)-8-Benzyloxy-5-[2-(4,7-dimethoxy-indan-2-ylamino)-1-hydroxy-ethyl]-1H-quinolin-2-one

Guidance literature:

In toluene; at 110 ℃; for 4h;

Reference yield:

2,3-dihydro-4,7-dimethoxy-1H-inden-2-amine (79381-08-1) + propionic acid (802294-64-0,79-09-4) → RDS 127 (82668-32-4)

Guidance literature:

With sodium tetrahydroborate; Multistep reaction; 1.) benzene, 5-10 deg C; 2.) benzene, reflux, 4 h;

DOI:10.1021/jm00349a019

upstream raw materials:

4,7-dimethoxyindan-1-one

Downstream raw materials:

RDS 127

Refernces