4-{[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}-N-phenylaniline

Base Information

Chemical Name:4-{[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}-N-phenylaniline
CAS No.:1402149-93-2
Molecular Formula:C₄₀H₄₀N₆O₄S
Molecular Weight:700.861
Hs Code.:

4-{[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}-N-phenylaniline

Synonyms:4-{[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}-N-phenylaniline

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Chemical Property of 4-{[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}-N-phenylaniline

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Technology Process of 4-{[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}-N-phenylaniline

There total 8 articles about 4-{[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}-N-phenylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1402149-91-0
4-{[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl trifluoromethanesulfonate

: 62-53-3
aniline

: 1402149-93-2
4-{[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}-N-phenylaniline

Guidance literature:: With palladium diacetate; caesium carbonate; johnphos; In toluene; at 100 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1021/jm300624s

Reference yield:

: 1402149-74-9
4-[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-zl]methyl phenol

: 1402149-93-2
4-{[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}-N-phenylaniline

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: palladium diacetate; caesium carbonate; johnphos / toluene / 100 °C / Schlenk technique; Inert atmosphere

With palladium diacetate; caesium carbonate; triethylamine; johnphos; In dichloromethane; toluene;
DOI:10.1021/jm300624s

Reference yield:

: 4692-98-2
5-bromoisatoic anhydride

: 1402149-93-2
4-{[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}-N-phenylaniline

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine; dmap / Reflux; Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

3.1: pyridine / 16 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water / 80 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: palladium diacetate; caesium carbonate; johnphos / toluene / 100 °C / Schlenk technique; Inert atmosphere

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; johnphos; In tetrahydrofuran; dichloromethane; water; toluene; 5.1: |Suzuki Coupling;
DOI:10.1021/jm300624s