11a-benzyl-9-oxo-6,7,9,10,11,11a-hexahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide

Base Information

Chemical Name:11a-benzyl-9-oxo-6,7,9,10,11,11a-hexahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide
CAS No.:1400926-28-4
Molecular Formula:C₂₉H₂₈N₂O₂
Molecular Weight:436.554
Hs Code.:

Synonyms:11a-benzyl-9-oxo-6,7,9,10,11,11a-hexahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide

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Chemical Property of 11a-benzyl-9-oxo-6,7,9,10,11,11a-hexahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide

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Technology Process of 11a-benzyl-9-oxo-6,7,9,10,11,11a-hexahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide

There total 9 articles about 11a-benzyl-9-oxo-6,7,9,10,11,11a-hexahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3430-10-2
2-methyl-3-pyridinamine

: C₂₃H₂₂O₃

: 1400926-28-4
11a-benzyl-9-oxo-6,7,9,10,11,11a-hexahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In tetrahydrofuran; at 20 - 60 ℃; for 18.25h;

Reference yield:

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 1400926-28-4
11a-benzyl-9-oxo-6,7,9,10,11,11a-hexahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / n-heptane; dimethyl sulfoxide; tetrahydrofuran; mineral oil / 0.5 h / 20 °C

1.2: 4 h

2.1: [hydroxy(tosyloxy)iodo]benzene / water; methanol / 0 - 20 °C

3.1: pyrrolidine / toluene / 2 h / Reflux

3.2: 18 h / 100 °C

3.3: 2 h / 100 °C

4.1: ethanol; sodium / 3 h / 60 °C / Inert atmosphere; Reflux

5.1: methanesulfonic acid; DL-methionine / 48 h / 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

7.1: triethylamine / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere

8.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 1 h / 50 °C

8.2: pH ~ 1

9.1: N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate / tetrahydrofuran / 18.25 h / 20 - 60 °C

With pyrrolidine; methanesulfonic acid; lithium hydroxide monohydrate; ethanol; [hydroxy(tosyloxy)iodo]benzene; water; sodium; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; DL-methionine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 40463-28-3
2-methoxy-5,7,8,9-tetrahydrobenzocyclohepten-6-one

: 1400926-28-4
11a-benzyl-9-oxo-6,7,9,10,11,11a-hexahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyrrolidine / toluene / 2 h / Reflux

1.2: 18 h / 100 °C

1.3: 2 h / 100 °C

2.1: ethanol; sodium / 3 h / 60 °C / Inert atmosphere; Reflux

3.1: methanesulfonic acid; DL-methionine / 48 h / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

5.1: triethylamine / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 1 h / 50 °C

6.2: pH ~ 1

7.1: N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate / tetrahydrofuran / 18.25 h / 20 - 60 °C

With pyrrolidine; methanesulfonic acid; lithium hydroxide monohydrate; ethanol; water; sodium; triethylamine; N-ethyl-N,N-diisopropylamine; DL-methionine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;