5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-(methylthio)-indolin-2-one

Base Information

• Chemical Name: 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-(methylthio)-indolin-2-one
• CAS No.: 138937-57-2
• Molecular Formula: C₁₆H₁₀ClF₄NO₂S
• Molecular Weight: 391.774

Synonyms:5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-(methylthio)-indolin-2-one

Chemical Property of 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-(methylthio)-indolin-2-one

Chemical Property:

Purity/Quality:

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Technology Process of 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-(methylthio)-indolin-2-one

There total 4 articles about 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-(methylthio)-indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

[2-Amino-5-(2-chloro-6-fluoro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester (1028265-03-3) → 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-(methylthio)-indolin-2-one (138937-57-2)

Guidance literature:

toluene-4-sulfonic acid; In toluene; Heating;

DOI:10.1021/jo00043a044

Reference yield:

4-amino-phenol (123-30-8) → 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-(methylthio)-indolin-2-one (138937-57-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / K₂CO₃ / acetonitrile / 25 h / Heating

2: 1) chlorine, 2) triethylamine / 1) CH₂Cl₂, -78 deg C, 5-10 min, 2) a) -78 deg C, 1-1.5 h, b) up to RT, 1-2 h

3: 43 percent / p-toluenesulfonic acid / toluene / Heating

With chlorine; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In toluene; acetonitrile;

DOI:10.1021/jo00043a044

Reference yield:

3,4-difluoro-5-chloro-α,α,α-trifluorotoluene (77227-99-7) → 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-(methylthio)-indolin-2-one (138937-57-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / K₂CO₃ / acetonitrile / 25 h / Heating

2: 1) chlorine, 2) triethylamine / 1) CH₂Cl₂, -78 deg C, 5-10 min, 2) a) -78 deg C, 1-1.5 h, b) up to RT, 1-2 h

3: 43 percent / p-toluenesulfonic acid / toluene / Heating

With chlorine; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In toluene; acetonitrile;

DOI:10.1021/jo00043a044

upstream raw materials:

[2-Amino-5-(2-chloro-6-fluoro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester

4-amino-phenol

3,4-difluoro-5-chloro-α,α,α-trifluorotoluene

p-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>aniline

Downstream raw materials:

5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>indolin-2-one

5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-1-methyl-indolin-2-one

5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-1,3-dimethylindolin-2-one

5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-isopropylideneindolin-2-one

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