2-(1H-benzotriazol-1-yl)-2-(2-chlorophenyl)-3-(trimethylsilyl)propanal

Base Information

Chemical Name:2-(1H-benzotriazol-1-yl)-2-(2-chlorophenyl)-3-(trimethylsilyl)propanal
CAS No.:241466-91-1
Molecular Formula:C₁₈H₂₀ClN₃OSi
Molecular Weight:357.915
Hs Code.:

Synonyms:2-(1H-benzotriazol-1-yl)-2-(2-chlorophenyl)-3-(trimethylsilyl)propanal

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Chemical Property of 2-(1H-benzotriazol-1-yl)-2-(2-chlorophenyl)-3-(trimethylsilyl)propanal

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Technology Process of 2-(1H-benzotriazol-1-yl)-2-(2-chlorophenyl)-3-(trimethylsilyl)propanal

There total 2 articles about 2-(1H-benzotriazol-1-yl)-2-(2-chlorophenyl)-3-(trimethylsilyl)propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 196861-96-8
1-[1-(2-Chloro-phenyl)-2-trimethylsilanyl-ethyl]-1H-benzotriazole

: 241466-91-1
2-(1H-benzotriazol-1-yl)-2-(2-chlorophenyl)-3-(trimethylsilyl)propanal

Guidance literature:: N,N-dimethyl-formamide; 1-[1-(2-Chloro-phenyl)-2-trimethylsilanyl-ethyl]-1H-benzotriazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 3h;

With acetic acid; In tetrahydrofuran; at -78 - 20 ℃; for 16h;
DOI:10.1021/jo982493k

Reference yield:

: 241467-05-0
N-[(E)-2-(1H-benzotriazol-1-yl)-2-(2-chlorophenyl)-3-(trimethylsilyl)propylidene]aniline

: 241466-91-1
2-(1H-benzotriazol-1-yl)-2-(2-chlorophenyl)-3-(trimethylsilyl)propanal

Guidance literature:: Multi-step reaction with 2 steps

1.1: 46 percent / TBAF / tetrahydrofuran

2.1: n-BuLi / tetrahydrofuran / 3 h / -78 °C

2.2: 65 percent / glac. AcOH / tetrahydrofuran / 16 h / -78 - 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1.1: Elimination / 2.1: Addition / 2.2: Formylation;
DOI:10.1021/jo982493k