6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-4-phenyl-1,2,4-triazine-3,5(2H,4H)-dione

Base Information

Chemical Name:6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-4-phenyl-1,2,4-triazine-3,5(2H,4H)-dione
CAS No.:1353871-79-0
Molecular Formula:C₁₅H₁₃N₅O₄
Molecular Weight:327.299
Hs Code.:

Synonyms:6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-4-phenyl-1,2,4-triazine-3,5(2H,4H)-dione

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Chemical Property of 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-4-phenyl-1,2,4-triazine-3,5(2H,4H)-dione

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Technology Process of 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-4-phenyl-1,2,4-triazine-3,5(2H,4H)-dione

There total 4 articles about 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-4-phenyl-1,2,4-triazine-3,5(2H,4H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxy-1-methyl-1H-pyrazole hydrochloride: 33641-16-6
5-hydroxy-1-methyl-1H-pyrazole hydrochloride

: 1353873-55-8
2-methyl-3,5-dioxo-4-phenyl-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonyl chloride

: 1353871-79-0
6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-4-phenyl-1,2,4-triazine-3,5(2H,4H)-dione

Guidance literature:: 5-hydroxy-1-methyl-1H-pyrazole hydrochloride; 2-methyl-3,5-dioxo-4-phenyl-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonyl chloride; With triethylamine; In dichloromethane; for 0.5h; Cooling with ice;

With triethylamine; 2-hydroxy-2-methylpropanenitrile; In acetonitrile; for 0.5h; Reflux;

Reference yield:

: 19102-24-0
2-methyl-4-phenyl semicarbazide

: 1353871-79-0
6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-4-phenyl-1,2,4-triazine-3,5(2H,4H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 2 h / 20 °C / Reflux

1.2: 2 h / 20 °C

2.1: hydrogenchloride; acetic acid / water / 24 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 0.5 h / Cooling with ice

4.2: 0.5 h / Reflux

With hydrogenchloride; oxalyl dichloride; toluene-4-sulfonic acid; acetic acid; triethylamine; N,N-dimethyl-formamide; In dichloromethane; water; toluene;

Reference yield:

: 1353871-90-5
2-methyl-3,5-dioxo-4-phenyl-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxylic acid, ethyl ester

: 1353871-79-0
6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-4-phenyl-1,2,4-triazine-3,5(2H,4H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; acetic acid / water / 24 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

3.1: triethylamine / dichloromethane / 0.5 h / Cooling with ice

3.2: 0.5 h / Reflux

With hydrogenchloride; oxalyl dichloride; acetic acid; triethylamine; N,N-dimethyl-formamide; In dichloromethane; water;