[(2S,3S)-3-methyl-1-(triphenylmethyl)aziridin-2-yl]methanol

Base Information

Chemical Name:[(2S,3S)-3-methyl-1-(triphenylmethyl)aziridin-2-yl]methanol
CAS No.:167502-57-0
Molecular Formula:C₂₃H₂₃NO
Molecular Weight:329.442
Hs Code.:
European Community (EC) Number:967-444-3
Nikkaji Number:J651.748J,J756.319A

Synonyms:167502-57-0;[(2S,3S)-3-methyl-1-(triphenylmethyl)aziridin-2-yl]methanol;[(2S,3S)-3-methyl-1-tritylaziridin-2-yl]methanol;EN300-345920

Suppliers and Price of [(2S,3S)-3-methyl-1-(triphenylmethyl)aziridin-2-yl]methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of [(2S,3S)-3-methyl-1-(triphenylmethyl)aziridin-2-yl]methanol

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:329.177964357
Heavy Atom Count:25
Complexity:372

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1C(N1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)CO
Isomeric SMILES:C[C@H]1[C@H](N1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)CO

Technology Process of [(2S,3S)-3-methyl-1-(triphenylmethyl)aziridin-2-yl]methanol

There total 3 articles about [(2S,3S)-3-methyl-1-(triphenylmethyl)aziridin-2-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.4%

: 74481-56-4
methyl (2S,3S)-N-triphenylmethyl-3-methylaziridine-2-carboxylate

: 167502-57-0
(2S,3S)-2-hydroxymethyl-3-methyl-1-(triphenylmethyl)aziridine

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; for 3h; Ambient temperature;
DOI:10.1248/cpb.42.2241

Reference yield:

: 76-83-5
trityl chloride

: 167502-57-0
(2S,3S)-2-hydroxymethyl-3-methyl-1-(triphenylmethyl)aziridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / Et₃N / CHCl₃ / 72 h / 0 °C

2.1: methanesulfonyl chloride / pyridine / 24 h / -10 - 20 °C

2.2: 66 percent / Et₃N / tetrahydrofuran / 40 h / Heating

3.1: diisobutylaluminium hydride / CH₂Cl₂; hexane / 3 h / -70 - 20 °C

3.2: 67 percent / ammonium chloride / diethyl ether; hexane / -70 °C

With diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; In pyridine; hexane; dichloromethane; chloroform;
DOI:10.1021/ol0170152

Reference yield:

: 74481-55-3
methyl (2S,3R)-3-hydroxy-2-triphenylmethylaminobutanoate

: 167502-57-0
(2S,3S)-2-hydroxymethyl-3-methyl-1-(triphenylmethyl)aziridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanesulfonyl chloride / pyridine / 24 h / -10 - 20 °C

1.2: 66 percent / Et₃N / tetrahydrofuran / 40 h / Heating

2.1: diisobutylaluminium hydride / CH₂Cl₂; hexane / 3 h / -70 - 20 °C

2.2: 67 percent / ammonium chloride / diethyl ether; hexane / -70 °C

With diisobutylaluminium hydride; methanesulfonyl chloride; In pyridine; hexane; dichloromethane;
DOI:10.1021/ol0170152