Benzyl-{(1R,2R)-2-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-1-hydroxymethyl-ethyl}-carbamic acid benzyl ester

Base Information

Chemical Name:Benzyl-{(1R,2R)-2-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-1-hydroxymethyl-ethyl}-carbamic acid benzyl ester
CAS No.:132548-20-0
Molecular Formula:C₃₀H₄₅NO₇Si
Molecular Weight:559.775
Hs Code.:

Benzyl-{(1R,2R)-2-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-1-hydroxymethyl-ethyl}-carbamic acid benzyl ester

Synonyms:Benzyl-{(1R,2R)-2-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-1-hydroxymethyl-ethyl}-carbamic acid benzyl ester

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Chemical Property of Benzyl-{(1R,2R)-2-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-1-hydroxymethyl-ethyl}-carbamic acid benzyl ester

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Technology Process of Benzyl-{(1R,2R)-2-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-1-hydroxymethyl-ethyl}-carbamic acid benzyl ester

There total 3 articles about Benzyl-{(1R,2R)-2-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-1-hydroxymethyl-ethyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 132548-19-7
(1R,2R)-2-Benzylamino-1-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-propane-1,3-diol

: 501-53-1,94274-21-2
benzyl chloroformate

: 132548-20-0
Benzyl-{(1R,2R)-2-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-1-hydroxymethyl-ethyl}-carbamic acid benzyl ester

Guidance literature:: With sodium carbonate; In dichloromethane;
DOI:10.1039/c39900001457

Reference yield:

: 108818-00-4
(E)-(4S,5S)-6-<(tert-Butyldimethylsilyl)oxy>-4,5-O-(1-methylethylidene)-2-hexen-1-ol

: 132548-20-0
Benzyl-{(1R,2R)-2-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-1-hydroxymethyl-ethyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: (+)-DET, (i-PrO)4Ti, TBHP

2: 70 percent / CH₂Cl₂ / 0 °C

3: 98 percent / aq. Na₂CO₃ / CH₂Cl₂

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; sodium carbonate; In dichloromethane;
DOI:10.1039/c39900001457

Reference yield:

: 108818-01-5
(2S,3R,4S,5S)-6-<(tert-butyldimethylsilyl)oxy>-2,3-epoxy-4,5-(isopropylidenedioxy)hexan-1-ol

: 132548-20-0
Benzyl-{(1R,2R)-2-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-1-hydroxymethyl-ethyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / CH₂Cl₂ / 0 °C

2: 98 percent / aq. Na₂CO₃ / CH₂Cl₂

With sodium carbonate; In dichloromethane;
DOI:10.1039/c39900001457