3-{(Z)-1-fluoro-2-[3-fluoro-4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1H-pyrazole

Base Information

Chemical Name:3-{(Z)-1-fluoro-2-[3-fluoro-4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1H-pyrazole
CAS No.:1418297-00-3
Molecular Formula:C₁₆H₁₅F₅N₂
Molecular Weight:330.301
Hs Code.:

Synonyms:3-{(Z)-1-fluoro-2-[3-fluoro-4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1H-pyrazole

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Chemical Property of 3-{(Z)-1-fluoro-2-[3-fluoro-4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1H-pyrazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-{(Z)-1-fluoro-2-[3-fluoro-4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1H-pyrazole

There total 15 articles about 3-{(Z)-1-fluoro-2-[3-fluoro-4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1418297-02-5
3-{(Z)-1-fluoro-2-[3-fluoro-4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole

: 1418297-00-3
3-{(Z)-1-fluoro-2-[3-fluoro-4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1H-pyrazole

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418297-00-3
3-{(Z)-1-fluoro-2-[3-fluoro-4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418297-00-3
3-{(Z)-1-fluoro-2-[3-fluoro-4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

3.1: N,N-dimethyl-formamide / 1 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

5.2: 16 h / -78 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;