C₁₆H₁₁F₄NOS

Base Information

• Chemical Name: C₁₆H₁₁F₄NOS
• CAS No.: 1442676-46-1
• Molecular Formula: C₁₆H₁₁F₄NOS
• Molecular Weight: 341.329
• Mol file: 1442676-46-1.mol

Synonyms:C₁₆H₁₁F₄NOS

Chemical Property of C₁₆H₁₁F₄NOS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₁F₄NOS

There total 3 articles about C₁₆H₁₁F₄NOS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

ethyl 4-(4-fluorothiophenyl)-6,7,8-trifluoroquinoline-3-carboxylate → 4-(4-fluorophenylthio)-6,7,8-trifluoroquinoline-3-methanol + C16H11F4NOS (1442676-46-1)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -5 - 0 ℃; for 7h; Reagent/catalyst; Solvent; Temperature; Time; Inert atmosphere; Large scale;

DOI:10.1021/op400060z

Reference yield:

ethyl 6,7,8-trifluoro-4-hydroxyquinoline-3-carboxylate (79660-46-1,80104-36-5) → C16H11F4NOS (1442676-46-1)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / toluene / 2 h / Reflux; Large scale

2: sodium hydrogencarbonate / dichloromethane / 19 h / Reflux; Large scale

3: diisobutylaluminium hydride / toluene / 7 h / -5 - 0 °C / Inert atmosphere; Large scale

With diisobutylaluminium hydride; sodium hydrogencarbonate; trichlorophosphate; In dichloromethane; toluene;

DOI:10.1021/op400060z

Reference yield:

ethyl 4-chloro-6,7,8-trifluoroquinoline-3-carboxylate (207231-24-1) → C16H11F4NOS (1442676-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane / 19 h / Reflux; Large scale

2: diisobutylaluminium hydride / toluene / 7 h / -5 - 0 °C / Inert atmosphere; Large scale

With diisobutylaluminium hydride; sodium hydrogencarbonate; In dichloromethane; toluene;

DOI:10.1021/op400060z

upstream raw materials:

ethyl 6,7,8-trifluoro-4-hydroxyquinoline-3-carboxylate

ethyl 4-chloro-6,7,8-trifluoroquinoline-3-carboxylate