(R)-2-Azido-4-methyl-pentanoic acid [(S)-1-[(2,4-dimethoxy-benzyl)-prop-2-ynyl-carbamoyl]-2-(4-iodo-phenyl)-ethyl]-amide

Base Information

Chemical Name:(R)-2-Azido-4-methyl-pentanoic acid [(S)-1-[(2,4-dimethoxy-benzyl)-prop-2-ynyl-carbamoyl]-2-(4-iodo-phenyl)-ethyl]-amide
CAS No.:867335-84-0
Molecular Formula:C₂₇H₃₂IN₅O₄
Molecular Weight:617.487
Hs Code.:

Synonyms:(R)-2-Azido-4-methyl-pentanoic acid [(S)-1-[(2,4-dimethoxy-benzyl)-prop-2-ynyl-carbamoyl]-2-(4-iodo-phenyl)-ethyl]-amide

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Chemical Property of (R)-2-Azido-4-methyl-pentanoic acid [(S)-1-[(2,4-dimethoxy-benzyl)-prop-2-ynyl-carbamoyl]-2-(4-iodo-phenyl)-ethyl]-amide

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Technology Process of (R)-2-Azido-4-methyl-pentanoic acid [(S)-1-[(2,4-dimethoxy-benzyl)-prop-2-ynyl-carbamoyl]-2-(4-iodo-phenyl)-ethyl]-amide

There total 4 articles about (R)-2-Azido-4-methyl-pentanoic acid [(S)-1-[(2,4-dimethoxy-benzyl)-prop-2-ynyl-carbamoyl]-2-(4-iodo-phenyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-amino-N-(2,4-dimethoxy-benzyl)-3-(4-iodo-phenyl)-N-prop-2-ynyl-propionamide

: 126191-08-0
(R)-2-azido-4-methylpentanoic acid

: 867335-84-0
(R)-2-Azido-4-methyl-pentanoic acid [(S)-1-[(2,4-dimethoxy-benzyl)-prop-2-ynyl-carbamoyl]-2-(4-iodo-phenyl)-ethyl]-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 3h;
DOI:10.1021/ol0518028

Reference yield:

: N-(2,4-dimethoxybenzyl)propargylamine hydrochloride

: 867335-84-0
(R)-2-Azido-4-methyl-pentanoic acid [(S)-1-[(2,4-dimethoxy-benzyl)-prop-2-ynyl-carbamoyl]-2-(4-iodo-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / HATU; diisopropylethylamine / CH₂Cl₂; dimethylformamide / 3 h / 0 °C

2: Et₂NH / acetonitrile / 1 h

3: HATU; diisopropylethylamine / CH₂Cl₂; dimethylformamide / 3 h / 0 °C

With diethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol0518028

Reference yield:

: 867335-92-0
[1-[(2,4-dimethoxy-benzyl)-prop-2-ynyl-carbamoyl]-2-(4-iodo-phenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

: 867335-84-0
(R)-2-Azido-4-methyl-pentanoic acid [(S)-1-[(2,4-dimethoxy-benzyl)-prop-2-ynyl-carbamoyl]-2-(4-iodo-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₂NH / acetonitrile / 1 h

2: HATU; diisopropylethylamine / CH₂Cl₂; dimethylformamide / 3 h / 0 °C

With diethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol0518028