1-tert-Butyloxycarbonyl-4-benzyl-4fluoropiperidine

Base Information

Chemical Name:1-tert-Butyloxycarbonyl-4-benzyl-4fluoropiperidine
CAS No.:191327-88-5
Molecular Formula:C₁₇H₂₄FNO₂
Molecular Weight:293.381
Hs Code.:
DSSTox Substance ID:DTXSID701162204

Synonyms:SCHEMBL8115847;BMGWZYUNPYGNBN-UHFFFAOYSA-N;DTXSID701162204;1-tert-Butyloxycarbonyl-4-benzyl-4fluoropiperidine;1,1-Dimethylethyl 4-fluoro-4-(phenylmethyl)-1-piperidinecarboxylate;191327-88-5

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-tert-Butyloxycarbonyl-4-benzyl-4fluoropiperidine

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:293.17910717
Heavy Atom Count:21
Complexity:350

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)(CC2=CC=CC=C2)F

Technology Process of 1-tert-Butyloxycarbonyl-4-benzyl-4fluoropiperidine

There total 6 articles about 1-tert-Butyloxycarbonyl-4-benzyl-4fluoropiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 191327-87-4
tert-butyl 4-benzyl-4-hydroxypiperidine-1-carboxylate

: 191327-88-5
1-tert-butyloxycarbonyl-4-benzyl-4-fluoropiperidine

: 1-tert-butyloxycarbonyl-4-benzyl-1,2,5,6-tetrahydropyridine

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; a) -75 deg C, 50 min, b) -10 deg C, 2 h;
DOI:10.1021/jm981133m

Reference yield:

: 191327-87-4
tert-butyl 4-benzyl-4-hydroxypiperidine-1-carboxylate

: 191327-88-5
1-tert-butyloxycarbonyl-4-benzyl-4-fluoropiperidine

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 0 ℃;
DOI:10.1021/jm980204e

Reference yield:

: 51135-96-7
4-benzyl-4-hydroxypiperidine

: 191327-88-5
1-tert-butyloxycarbonyl-4-benzyl-4-fluoropiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / CH₂Cl₂ / 4 h / Ambient temperature

2: 51 percent / diethylaminodulfur trifluoride / CH₂Cl₂ / a) -75 deg C, 50 min, b) -10 deg C, 2 h

With diethylamino-sulfur trifluoride; In dichloromethane;
DOI:10.1021/jm981133m