N-benzyloxycarbonyl-2-[5-(2-fluoro-pyridin-4-yl)-1-methyl-4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-ethylamine

Base Information

• Chemical Name: N-benzyloxycarbonyl-2-[5-(2-fluoro-pyridin-4-yl)-1-methyl-4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-ethylamine
• CAS No.: 219511-19-0
• Molecular Formula: C₂₆H₂₂F₄N₄O₂
• Molecular Weight: 498.48

Synonyms:N-benzyloxycarbonyl-2-[5-(2-fluoro-pyridin-4-yl)-1-methyl-4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-ethylamine

Chemical Property of N-benzyloxycarbonyl-2-[5-(2-fluoro-pyridin-4-yl)-1-methyl-4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-ethylamine

Chemical Property:

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Technology Process of N-benzyloxycarbonyl-2-[5-(2-fluoro-pyridin-4-yl)-1-methyl-4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-ethylamine

There total 2 articles about N-benzyloxycarbonyl-2-[5-(2-fluoro-pyridin-4-yl)-1-methyl-4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2-{[1-(2-fluoro-pyridin-4-yl)-2-oxo-2-(3-trifluoromethyl-phenyl)-ethyl]-methyl-carbamoyl}-ethyl)-carbamic acid benzyl ester → N-benzyloxycarbonyl-2-[5-(2-fluoro-pyridin-4-yl)-1-methyl-4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-ethylamine (219511-19-0)

Guidance literature:

With ammonium trifluoroacetate; at 150 ℃; for 0.0833333h;

DOI:10.1016/S0040-4039(98)02058-9

Reference yield:

→ 1H-imidazole (288-32-4) + N-benzyloxycarbonyl-2-[5-(2-fluoro-pyridin-4-yl)-1-methyl-4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-ethylamine (219511-19-0)

Guidance literature:

Reference yield:

N-benzyloxycarbonyl-2-[5-(2-fluoro-pyridin-4-yl)-1-methyl-4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-ethylamine (219511-19-0) → (S)-1-phenyl-N-{4-[2-(2-(benzyloxycarbonyl-amino)ethyl)-3-methyl-5-(3-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-pyridin-2-yl}-ethylamine (319470-03-6)

Guidance literature:

With sodium hydroxide; citric acid; In (S)-1-phenyl-ethylamine;

Downstream raw materials:

(S)-1-phenyl-N-{4-[2-(2-(benzyloxycarbonyl-amino)ethyl)-3-methyl-5-(3-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-pyridin-2-yl}-ethylamine

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