methyl (Z)-2-(isothioureidomethyl)-3-(4-nitrophenyl)-2-propenoate hydrobromide

Base Information

• Chemical Name: methyl (Z)-2-(isothioureidomethyl)-3-(4-nitrophenyl)-2-propenoate hydrobromide
• CAS No.: 1255193-96-4
• Molecular Formula: BrH*C₁₂H₁₃N₃O₄S
• Molecular Weight: 376.231
• Mol file: 1255193-96-4.mol

Synonyms:methyl (Z)-2-(isothioureidomethyl)-3-(4-nitrophenyl)-2-propenoate hydrobromide

Chemical Property of methyl (Z)-2-(isothioureidomethyl)-3-(4-nitrophenyl)-2-propenoate hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (Z)-2-(isothioureidomethyl)-3-(4-nitrophenyl)-2-propenoate hydrobromide

There total 2 articles about methyl (Z)-2-(isothioureidomethyl)-3-(4-nitrophenyl)-2-propenoate hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl (Z)-2-(bromomethyl)-3-(4-nitrophenyl)-2-propenoate (137104-37-1) + thiourea (17356-08-0) → methyl (Z)-2-(isothioureidomethyl)-3-(4-nitrophenyl)-2-propenoate hydrobromide (1255193-96-4)

Guidance literature:

In water; acetone; at 25 ℃; for 1h;

DOI:10.3998/ark.5550190.0011.b24

Reference yield:

methyl 2-[hydroxy(4-nitrophenyl)methyl]prop-2-enoate (114106-93-3) → methyl (Z)-2-(isothioureidomethyl)-3-(4-nitrophenyl)-2-propenoate hydrobromide (1255193-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium bromide; sulfuric acid / acetonitrile / 25 °C

2: acetone; water / 1 h / 25 °C

With sulfuric acid; lithium bromide; In water; acetone; acetonitrile;

DOI:10.1016/j.ejmech.2017.02.013

Reference yield: 95.0%

methyl (Z)-2-(isothioureidomethyl)-3-(4-nitrophenyl)-2-propenoate hydrobromide (1255193-96-4) + acetic anhydride (108-24-7) → methyl (Z)-2-[(N,N'-diacetylisothioureido)methyl]-3-(4-nitrophenyl)-2-propenoate (1255194-14-9)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; at 25 ℃; for 0.25h;

DOI:10.3998/ark.5550190.0011.b24

upstream raw materials:

methyl (Z)-2-(bromomethyl)-3-(4-nitrophenyl)-2-propenoate

thiourea

methyl 2-[hydroxy(4-nitrophenyl)methyl]prop-2-enoate

Downstream raw materials:

(5Z)-2-amino-5,6-dihydro-[5-(4-nitrobenzylidene)]-1,3-thiazin-4-one

methyl (Z)-2-[(N,N'-diacetylisothioureido)methyl]-3-(4-nitrophenyl)-2-propenoate