ethyl 4-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}butanoate

Base Information

Chemical Name:ethyl 4-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}butanoate
CAS No.:1334608-08-0
Molecular Formula:C₃₂H₄₀ClN₃O₃
Molecular Weight:550.141
Hs Code.:

Synonyms:ethyl 4-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}butanoate

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Chemical Property of ethyl 4-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}butanoate

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Technology Process of ethyl 4-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}butanoate

There total 11 articles about ethyl 4-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2969-81-5
Ethyl 4-bromobutyrate

: 1334608-06-8
2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-[2-ethyl-3-(4-piperidinyl)phenyl]pyrimidine

: 1334608-08-0
ethyl 4-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}butanoate

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 3h; Inert atmosphere; Sealed;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1334608-08-0
ethyl 4-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}butanoate

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2: hydrogenchloride; acetic acid / water / 12 h / Reflux

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 90 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 12 h / 50 °C / 2844.39 Torr

5: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

6: potassium carbonate / acetonitrile / 3 h / 80 °C / Inert atmosphere; Sealed

With hydrogenchloride; n-butyllithium; hydrogen; potassium acetate; potassium carbonate; caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; hexane; water; ethyl acetate; acetonitrile;

Reference yield:

: 201849-21-0
4-bromo-2-chloro-1-[(1-methylethyl)oxy]benzene

: 1334608-08-0
ethyl 4-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 20 - 80 °C / Inert atmosphere

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere

3: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

4: potassium carbonate / acetonitrile / 3 h / 80 °C / Inert atmosphere; Sealed

With potassium acetate; sodium carbonate; potassium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;