Phosphoric acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
• CAS No.: 86359-89-9
• Molecular Formula: C₃₈H₄₀N₅O₁₁P
• Molecular Weight: 773.736

Synonyms:Phosphoric acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Chemical Property of Phosphoric acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Technology Process of Phosphoric acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

There total 5 articles about Phosphoric acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Phosphoric acid (2R,3S,5R)-3-hydroxy-5-[4-(4-methoxy-phenylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with pyridine → Phosphoric acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (86359-89-9)

Guidance literature:

With ammonia; In methanol; for 16h;

DOI:10.1002/hlca.19830660131

Reference yield:

C35H31ClN2O8P(1-)*C8H20N(1+) → Phosphoric acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (86359-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / 1-(mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole / pyridine / 0.58 h

2: (E)-p-nitrobenzaldoxime

3: 87 percent / NH₃ / methanol / 16 h

With 4-nitrobenzaldehyde oxime; ammonia; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In pyridine; methanol;

DOI:10.1002/hlca.19830660131

Reference yield:

3'-O-Acetyl-N4-anisoyl-2'-desoxycytidin-5'-phosphat Pyridiniumsalz → Phosphoric acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (86359-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / pyridine / 144 h

2: 87 percent / NH₃ / methanol / 16 h

With ammonia; dicyclohexyl-carbodiimide; In pyridine; methanol;

DOI:10.1002/hlca.19830660131

upstream raw materials:

1-[O⁵-(4-methoxy-trityl)-β-D-erythro-2-deoxy-pentofuranosyl]-1H-pyrimidin-2-one

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