(S)-4-(4-aminophenylthio)-3-(7-isopropylquinazolin-4-ylamino)-N-(1-phenylethyl)benzamide

Base Information

Chemical Name:(S)-4-(4-aminophenylthio)-3-(7-isopropylquinazolin-4-ylamino)-N-(1-phenylethyl)benzamide
CAS No.:943780-22-1
Molecular Formula:C₃₂H₃₁N₅OS
Molecular Weight:533.697
Hs Code.:

Synonyms:(S)-4-(4-aminophenylthio)-3-(7-isopropylquinazolin-4-ylamino)-N-(1-phenylethyl)benzamide

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Chemical Property of (S)-4-(4-aminophenylthio)-3-(7-isopropylquinazolin-4-ylamino)-N-(1-phenylethyl)benzamide

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Technology Process of (S)-4-(4-aminophenylthio)-3-(7-isopropylquinazolin-4-ylamino)-N-(1-phenylethyl)benzamide

There total 8 articles about (S)-4-(4-aminophenylthio)-3-(7-isopropylquinazolin-4-ylamino)-N-(1-phenylethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 943780-25-4
tert-butyl (S)-4-(2-(7-isopropylquinazolin-4-ylamino)-4-(1-phenylethylcarbamoyl)phenylthio)phenylcarbamate

: 943780-22-1
(S)-4-(4-aminophenylthio)-3-(7-isopropylquinazolin-4-ylamino)-N-(1-phenylethyl)benzamide

Guidance literature:: tert-butyl (S)-4-(2-(7-isopropylquinazolin-4-ylamino)-4-(1-phenylethylcarbamoyl)phenylthio)phenylcarbamate; With trifluoroacetic acid; In dichloromethane;

With sodium hydrogencarbonate; In water;

Reference yield:

: 586-61-8
4-iso-propylbromobenzene

: 943780-22-1
(S)-4-(4-aminophenylthio)-3-(7-isopropylquinazolin-4-ylamino)-N-(1-phenylethyl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitric acid / water / 2 h / 5 - 10 °C

2.1: N,N-dimethyl-formamide / 1.5 h / 160 °C

2.2: 0.33 h / 65 °C

3.1: sulfuric acid; water / acetic acid / 72 h / Heating / reflux

3.2: 0 °C / pH 12

3.3: pH 2

4.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 760.05 Torr

5.1: 0.5 h / 150 °C

6.1: trichlorophosphate / 1 h / Heating / reflux

7.1: ethanol / 1 h / Heating / reflux

8.1: trifluoroacetic acid / dichloromethane

With sulfuric acid; water; hydrogen; nitric acid; trifluoroacetic acid; trichlorophosphate; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 35480-95-6
4-isopropyl-2-nitro-benzoic acid

: 943780-22-1
(S)-4-(4-aminophenylthio)-3-(7-isopropylquinazolin-4-ylamino)-N-(1-phenylethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 760.05 Torr

2: 0.5 h / 150 °C

3: trichlorophosphate / 1 h / Heating / reflux

4: ethanol / 1 h / Heating / reflux

5: trifluoroacetic acid / dichloromethane

With hydrogen; trifluoroacetic acid; trichlorophosphate; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane;