Technology Process of Phosphoric acid (4E,8E,12E,16E,20E)-1-isopropenyl-4,8,12,16,20-pentamethyl-22-(2,3,4,5-tetramethoxy-6-methyl-phenyl)-docosa-4,8,12,16,20-pentaenyl ester diisopropyl ester
There total 7 articles about Phosphoric acid (4E,8E,12E,16E,20E)-1-isopropenyl-4,8,12,16,20-pentamethyl-22-(2,3,4,5-tetramethoxy-6-methyl-phenyl)-docosa-4,8,12,16,20-pentaenyl ester diisopropyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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139137-98-7
Phosphoric acid (4E,8E,12E,16E,20E)-1-isopropenyl-4,8,12,16,20-pentamethyl-22-(2,3,4,5-tetramethoxy-6-methyl-phenyl)-docosa-4,8,12,16,20-pentaenyl ester diisopropyl ester
- Guidance literature:
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Multi-step reaction with 7 steps
1: 50 percent / mCPBA / CH2Cl2 / 1 h / 0 °C
2: (i-Pr)2NAlEt2 / diethyl ether; hexane / 0.5 h / 0 °C
3: 1) BuLi / 1) THF, hexane, a) -78 deg C, 10 min, b) 0 deg C, 10 min, 2) 0 deg C, 15 min
4: 1) CuCN*2LiCl / 1) THF, a) -30 deg C, 10 min, b) 0 deg C, 20 min, 2) THF, -60 deg C, 2 h
5: N-bromosuccinimide / tetrahydrofuran; H2O / 1 h / Ambient temperature
6: NaOMe / methanol / 0.5 h / 0 °C
7: 1) (i-Pr)2NAlEt2, 2) BuLi / 1) Et2O, hexane, 0 deg C, 1 h, 2) THF, 0 deg C, 1.5 h
With
N-Bromosuccinimide; n-butyllithium; diisopropylamino diethylaluminium; sodium methylate; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water;
DOI:10.1055/s-1991-28404
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139137-98-7
Phosphoric acid (4E,8E,12E,16E,20E)-1-isopropenyl-4,8,12,16,20-pentamethyl-22-(2,3,4,5-tetramethoxy-6-methyl-phenyl)-docosa-4,8,12,16,20-pentaenyl ester diisopropyl ester
- Guidance literature:
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Multi-step reaction with 6 steps
1: (i-Pr)2NAlEt2 / diethyl ether; hexane / 0.5 h / 0 °C
2: 1) BuLi / 1) THF, hexane, a) -78 deg C, 10 min, b) 0 deg C, 10 min, 2) 0 deg C, 15 min
3: 1) CuCN*2LiCl / 1) THF, a) -30 deg C, 10 min, b) 0 deg C, 20 min, 2) THF, -60 deg C, 2 h
4: N-bromosuccinimide / tetrahydrofuran; H2O / 1 h / Ambient temperature
5: NaOMe / methanol / 0.5 h / 0 °C
6: 1) (i-Pr)2NAlEt2, 2) BuLi / 1) Et2O, hexane, 0 deg C, 1 h, 2) THF, 0 deg C, 1.5 h
With
N-Bromosuccinimide; n-butyllithium; diisopropylamino diethylaluminium; sodium methylate;
In
tetrahydrofuran; methanol; diethyl ether; hexane; water;
DOI:10.1055/s-1991-28404
-
-
139137-98-7
Phosphoric acid (4E,8E,12E,16E,20E)-1-isopropenyl-4,8,12,16,20-pentamethyl-22-(2,3,4,5-tetramethoxy-6-methyl-phenyl)-docosa-4,8,12,16,20-pentaenyl ester diisopropyl ester
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) BuLi / 1) THF, hexane, a) -78 deg C, 10 min, b) 0 deg C, 10 min, 2) 0 deg C, 15 min
2: 1) CuCN*2LiCl / 1) THF, a) -30 deg C, 10 min, b) 0 deg C, 20 min, 2) THF, -60 deg C, 2 h
3: N-bromosuccinimide / tetrahydrofuran; H2O / 1 h / Ambient temperature
4: NaOMe / methanol / 0.5 h / 0 °C
5: 1) (i-Pr)2NAlEt2, 2) BuLi / 1) Et2O, hexane, 0 deg C, 1 h, 2) THF, 0 deg C, 1.5 h
With
N-Bromosuccinimide; n-butyllithium; diisopropylamino diethylaluminium; sodium methylate;
In
tetrahydrofuran; methanol; water;
DOI:10.1055/s-1991-28404
