18-(4-chlorophenyl)-17-cyclohexyl-4,9-dimethyl-10,10-dioxo-10λ6-thia-1,4,9,11-tetraaza-tricyclo[11.5.2.0(16,19)]icosa-13(20),14,16(19),17-tetraene-3,12-dione

Base Information

Chemical Name:18-(4-chlorophenyl)-17-cyclohexyl-4,9-dimethyl-10,10-dioxo-10λ6-thia-1,4,9,11-tetraaza-tricyclo[11.5.2.0(16,19)]icosa-13(20),14,16(19),17-tetraene-3,12-dione
CAS No.:1165793-63-4
Molecular Formula:C₂₉H₃₅ClN₄O₄S
Molecular Weight:571.14
Hs Code.:

18-(4-chlorophenyl)-17-cyclohexyl-4,9-dimethyl-10,10-dioxo-10λ6-thia-1,4,9,11-tetraaza-tricyclo[11.5.2.0(16,19)]icosa-13(20),14,16(19),17-tetraene-3,12-dione

Synonyms:18-(4-chlorophenyl)-17-cyclohexyl-4,9-dimethyl-10,10-dioxo-10λ6-thia-1,4,9,11-tetraaza-tricyclo[11.5.2.0(16,19)]icosa-13(20),14,16(19),17-tetraene-3,12-dione

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Chemical Property of 18-(4-chlorophenyl)-17-cyclohexyl-4,9-dimethyl-10,10-dioxo-10λ6-thia-1,4,9,11-tetraaza-tricyclo[11.5.2.0(16,19)]icosa-13(20),14,16(19),17-tetraene-3,12-dione

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Technology Process of 18-(4-chlorophenyl)-17-cyclohexyl-4,9-dimethyl-10,10-dioxo-10λ6-thia-1,4,9,11-tetraaza-tricyclo[11.5.2.0(16,19)]icosa-13(20),14,16(19),17-tetraene-3,12-dione

There total 7 articles about 18-(4-chlorophenyl)-17-cyclohexyl-4,9-dimethyl-10,10-dioxo-10λ6-thia-1,4,9,11-tetraaza-tricyclo[11.5.2.0(16,19)]icosa-13(20),14,16(19),17-tetraene-3,12-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1165793-63-4
18-(4-chlorophenyl)-17-cyclohexyl-4,9-dimethyl-10,10-dioxo-10λ6-thia-1,4,9,11-tetraaza-tricyclo[11.5.2.0(16,19)]icosa-13(20),14,16(19),17-tetraene-3,12-dione

Guidance literature:

Reference yield:

: 18-(4-chlorophenyl)-17-cyclohexyl-4,9-dimethyl-10,10-dioxo-10λ6-thia-1,4,9,11-tetraaza-tricyclo[11.5.2.0(16,19)]icosa-7,13(20),14,16(19),17-pentaene-3,12-dione

: 1165793-63-4
18-(4-chlorophenyl)-17-cyclohexyl-4,9-dimethyl-10,10-dioxo-10λ6-thia-1,4,9,11-tetraaza-tricyclo[11.5.2.0(16,19)]icosa-13(20),14,16(19),17-tetraene-3,12-dione

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 6h; under 760.051 Torr;
DOI:10.1016/j.bmcl.2012.03.097

Reference yield:

: 774214-19-6
[2-(4-chlorophenyl)-3-cyclohexyl-6-(methoxycarbonyl)-1H-indol-1-yl]acetic acid

: 1165793-63-4
18-(4-chlorophenyl)-17-cyclohexyl-4,9-dimethyl-10,10-dioxo-10λ6-thia-1,4,9,11-tetraaza-tricyclo[11.5.2.0(16,19)]icosa-13(20),14,16(19),17-tetraene-3,12-dione

Guidance literature:: Multi-step reaction with 5 steps

1: HATU / N,N-dimethyl-formamide / 6 h / 20 °C

2: water; sodium hydroxide / tetrahydrofuran; methanol / 24 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

4: Hoveyda-Grubbs catalyst first generation / 1,2-dichloro-ethane / 15 h / 80 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 20 °C / 760.05 Torr

With Hoveyda-Grubbs catalyst first generation; palladium 10% on activated carbon; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.097