2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Base Information

• Chemical Name: 2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid
• CAS No.: 1501180-15-9
• Molecular Formula: C₁₁H₇F₂NO₃S
• Molecular Weight: 271.244
• Mol file: 1501180-15-9.mol

Synonyms:2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Chemical Property of 2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

There total 3 articles about 2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 2-(2,6-difluoro-4-methoxy-phenyl)thiazole-4-carboxylate (1586045-15-9) → 2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid (1501180-15-9)

Guidance literature:

With water; lithium hydroxide; In methanol; at 20 ℃;

Reference yield:

(2,6-difluoro-4-methoxyphenyl)boronic acid (406482-20-0) + tri-tert-butyl phosphine (13716-12-6) + methyl 2-(2,6-difluoro-4-methoxy-phenyl)thiazole-4-carboxylate (1586045-15-9) + 2-bromo-thiazole-4-carboxylic acid methyl ester (170235-26-4) → 2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid (1501180-15-9)

Guidance literature:

With hydrogenchloride; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nitrogen; In tetrahydrofuran; methanol; n-heptane; water; toluene;

Reference yield:

(2,6-difluoro-4-methoxyphenyl)boronic acid (406482-20-0) → 2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid (1501180-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium fluoride; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran; water; toluene / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

2: lithium hydroxide; water / methanol / 20 °C

With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; water; lithium hydroxide; In tetrahydrofuran; methanol; water; toluene; 1: |Suzuki Coupling;

upstream raw materials:

(2,6-difluoro-4-methoxyphenyl)boronic acid

tri-tert-butyl phosphine

methyl 2-(2,6-difluoro-4-methoxy-phenyl)thiazole-4-carboxylate

2-bromo-thiazole-4-carboxylic acid methyl ester

Downstream raw materials:

N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxamide

N-(5-((2S,5R,6R)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxamide