1-{3-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-thiourea

Base Information

• Chemical Name: 1-{3-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-thiourea
• CAS No.: 199522-75-3
• Molecular Formula: C₂₈H₂₈BrCl₂N₅O₂S
• Molecular Weight: 649.439

Synonyms:1-{3-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-thiourea

Chemical Property of 1-{3-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-thiourea

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Technology Process of 1-{3-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-thiourea

There total 2 articles about 1-{3-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N1-(5-Bromo-pyridin-2-yl)-N1-(3,4-dichloro-benzyl)-propane-1,3-diamine (199522-69-5) → 1-{3-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-thiourea (199522-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / DCC / tetrahydrofuran / Ambient temperature

2: 2.06 g / Et₃N / tetrahydrofuran

With triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1021/jm980118e

Reference yield:

N-(4-amino-1-butyl)phthalimide hydrochloride (35517-18-1) + 3-propyl isothiocyanate (199522-70-8) → 1-{3-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-thiourea (199522-75-3)

Guidance literature:

With triethylamine; In tetrahydrofuran;

DOI:10.1021/jm980118e

Reference yield: 70.0%

1-{3-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-thiourea (199522-75-3) → 1-(4-Aminobutyl)-3-(3-(N-(5-bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)amino)propyl)thiourea

Guidance literature:

With hydrazine hydrate; In ethanol; for 8h; Heating;

DOI:10.1021/jm980118e

upstream raw materials:

N-(4-amino-1-butyl)phthalimide hydrochloride

3-propyl isothiocyanate

N¹-(5-Bromo-pyridin-2-yl)-N¹-(3,4-dichloro-benzyl)-propane-1,3-diamine

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