1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)-N-[(1-phenylethyl)sulfonyl]piperidine-4-carboxamide

Base Information

Chemical Name:1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)-N-[(1-phenylethyl)sulfonyl]piperidine-4-carboxamide
CAS No.:1204588-85-1
Molecular Formula:C₂₅H₃₀N₄O₄S
Molecular Weight:482.604
Hs Code.:

Synonyms:1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)-N-[(1-phenylethyl)sulfonyl]piperidine-4-carboxamide

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Chemical Property of 1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)-N-[(1-phenylethyl)sulfonyl]piperidine-4-carboxamide

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Technology Process of 1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)-N-[(1-phenylethyl)sulfonyl]piperidine-4-carboxamide

There total 6 articles about 1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)-N-[(1-phenylethyl)sulfonyl]piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1204588-80-6
1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)piperidine-4-carboxylic acid

: 502635-04-3
1-phenylethane-1-sulfonamide

: 1204588-85-1
1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)-N-[(1-phenylethyl)sulfonyl]piperidine-4-carboxamide

Guidance literature:: 1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)piperidine-4-carboxylic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

1-phenylethane-1-sulfonamide; In dichloromethane;

Reference yield:

: 1204588-78-2
tert-butyl 1-[5-(chlorocarbonyl)-3-cyano-6-methylpyridin-2-yl]piperidine-4-carboxylate

: 1204588-85-1
1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)-N-[(1-phenylethyl)sulfonyl]piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron(III)-acetylacetonate / tetrahydrofuran / 0 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane

With iron(III)-acetylacetonate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2014.04.001

Reference yield:

: 64119-42-2
ethyl 6-chloro-5-cyano-2-methylnicotinate

: 1204588-85-1
1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)-N-[(1-phenylethyl)sulfonyl]piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / acetonitrile / 0.08 h / 100 °C / Microwave irradiation

2: sodium hydroxide; water / 80 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.33 h / 0 - 20 °C

4: iron(III)-acetylacetonate / tetrahydrofuran / 0 °C

5: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane

With oxalyl dichloride; iron(III)-acetylacetonate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2014.04.001