<4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylic acid

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Chemical Name:<4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylic acid
CAS No.:169869-69-6
Molecular Formula:C₃₁H₃₈N₄O₆
Molecular Weight:562.666
Hs Code.:

Synonyms:<4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylic acid

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Chemical Property of <4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylic acid

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Technology Process of <4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylic acid

There total 12 articles about <4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 160557-09-5
methyl <4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate

: 169869-69-6
<4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; for 5.5h; Ambient temperature;
DOI:10.1016/0040-4020(95)00273-B

Reference yield:

: 327-56-0
D-norleucine

: 169869-69-6
<4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / 1 M aq. NaOH / ethanol

2: 56 percent / CH₂Cl₂ / -20 °C

3: 1.) LiN(SiMe₃)2 / 1.) THF, from -78 to -65 deg C, 2.) THF

4: 75 percent / AcCl / 16 h / Heating

5: 1.) MeI / 1.) reflux, 16 h, 2.) MeOH, reflux, 16 h

6: aq. NaHCO₃ / tetrahydrofuran

7: 0.1 M aq. LiOH / tetrahydrofuran

With lithium hydroxide; sodium hydroxide; sodium hydrogencarbonate; acetyl chloride; lithium hexamethyldisilazane; methyl iodide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/0957-4166(94)80075-8

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 169869-69-6
<4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaHCO₃ / tetrahydrofuran

2: 0.1 M aq. LiOH / tetrahydrofuran

With lithium hydroxide; sodium hydrogencarbonate; In tetrahydrofuran;
DOI:10.1016/0957-4166(94)80075-8