tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethylpropyl>benzoate

Base Information

Chemical Name:tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethylpropyl>benzoate
CAS No.:170799-59-4
Molecular Formula:C₂₃H₃₂N₄O₂
Molecular Weight:396.533
Hs Code.:

tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopenta<d>pyrimidin-5-yl)-1-ethylpropyl>benzoate

Synonyms:tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethylpropyl>benzoate

Suppliers and Price of tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethylpropyl>benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethylpropyl>benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethylpropyl>benzoate

There total 8 articles about tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethylpropyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9
guanidine hydrogen carbonate

: 170799-64-1
tert-butyl 4-<3-(2-cyano-3-methoxy-2-cyclopentenyl)-1-ethylpropyl>benzoate

: 170799-59-4
tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethylpropyl>benzoate

Guidance literature:: In tert-butyl alcohol; at 160 ℃; for 12h;
DOI:10.1248/cpb.43.829

Reference yield:

: 149324-86-7
4-(t-butoxycarbonyl)propiophenone

: 170799-59-4
tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethylpropyl>benzoate

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, 60 deg C, 3 h

2: H₂ / 10percent Pd/C

3: 97 percent / 1N NaOH / ethanol / 3 h / Ambient temperature

4: 87 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / -78 - 20 °C

5: triethylamine / CH₂Cl₂ / 1 h / -78 °C

6: NaI / acetone / 12 h / Ambient temperature

7: tributyltin, azobisisobutyronitrile / benzene / Heating

8: N,N-diisopropylethylamine / hexane; ethanol; acetonitrile / 5 h / Ambient temperature

9: 40 percent / 2-methyl-propan-2-ol / 12 h / 160 °C

With sodium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; hydrogen; tri-n-butyl-tin hydride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetone; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1248/cpb.43.829

Reference yield:

: 149325-55-3
4-{1-[1-Ethoxycarbonyl-meth-(E)-ylidene]-propyl}-benzoic acid tert-butyl ester

: 170799-59-4
tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-ethylpropyl>benzoate

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / 10percent Pd/C

2: 97 percent / 1N NaOH / ethanol / 3 h / Ambient temperature

3: 87 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / -78 - 20 °C

4: triethylamine / CH₂Cl₂ / 1 h / -78 °C

5: NaI / acetone / 12 h / Ambient temperature

6: tributyltin, azobisisobutyronitrile / benzene / Heating

7: N,N-diisopropylethylamine / hexane; ethanol; acetonitrile / 5 h / Ambient temperature

8: 40 percent / 2-methyl-propan-2-ol / 12 h / 160 °C

With sodium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; hydrogen; tri-n-butyl-tin hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetone; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1248/cpb.43.829