1-fluoronorhexestrol

Base Information

• Chemical Name: 1-fluoronorhexestrol
• CAS No.: 83303-93-9
• Molecular Formula: C₁₇H₁₉FO₂
• Molecular Weight: 274.335
• Mol file: 83303-93-9.mol

Synonyms:1-fluoronorhexestrol

Chemical Property of 1-fluoronorhexestrol

Chemical Property:

• Boiling Point: 400.4oC at 760 mmHg
• Flash Point: 195.9oC
• PSA: 94.83000
• Density: 1.161g/cm3
• LogP: 2.47520

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-fluoronorhexestrol

There total 2 articles about 1-fluoronorhexestrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(2R*,3S*)-2,3-bis<4-<(trifluoromethanesulfonyl)oxy>phenyl>-1-pentyl (83303-92-8) → (2R*,3S*)-2,3-bis(4-hydroxyphenyl)-1-fluoropentane (83303-93-9,94233-89-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In acetone; for 2h; Heating;

DOI:10.1021/jm00353a006

Reference yield:

(2R*,3S*)-2,3-bis(4-hydroxyphenyl)-1-pentanol (79568-19-7,79618-19-2,79618-20-5,83349-90-0) → (2R*,3S*)-2,3-bis(4-hydroxyphenyl)-1-fluoropentane (83303-93-9,94233-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h

2: 52 percent / n-Bu₄N⁽¹⁺⁾*F^(1-) / acetone / 2 h / Heating

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; In dichloromethane; acetone;

DOI:10.1021/jm00353a006

upstream raw materials:

(2R*,3S*)-2,3-bis<4-<(trifluoromethanesulfonyl)oxy>phenyl>-1-pentyl

(2R*,3S*)-2,3-bis(4-hydroxyphenyl)-1-pentanol

Refernces