1-(3-(azetidine-1-carbonyl)phenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione

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Chemical Name:1-(3-(azetidine-1-carbonyl)phenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
CAS No.:1456713-68-0
Molecular Formula:C₂₈H₂₅FIN₅O₄
Molecular Weight:641.441
Hs Code.:

Synonyms:1-(3-(azetidine-1-carbonyl)phenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione

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Chemical Property of 1-(3-(azetidine-1-carbonyl)phenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione

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Technology Process of 1-(3-(azetidine-1-carbonyl)phenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione

There total 5 articles about 1-(3-(azetidine-1-carbonyl)phenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1456714-59-2
5-((3-(azetidine-1-carbonyl)phenyl)amino)-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione

: 1456713-68-0
1-(3-(azetidine-1-carbonyl)phenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione

Guidance literature:: With sodium methylate; In tetrahydrofuran; methanol; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1118819-89-8
tert-butyl (3-(azetidine-1-carbonyl)phenyl)carbamate

: 1456713-68-0
1-(3-(azetidine-1-carbonyl)phenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: 2,6-dimethylpyridine / N,N-dimethyl acetamide / 16 h / 130 °C / Inert atmosphere; Sealed tube

3: sodium methylate / methanol; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium methylate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 99-05-8,159139-79-4
meta-aminobenzoic acid

: 1456713-68-0
1-(3-(azetidine-1-carbonyl)phenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / water; 1,4-dioxane / 12 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4: 2,6-dimethylpyridine / N,N-dimethyl acetamide / 16 h / 130 °C / Inert atmosphere; Sealed tube

5: sodium methylate / methanol; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium methylate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;