1-{5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-2'-fluoro-3'-(hydroxyamino)-β-D-arabinofuranosyl}uracil

Base Information

Chemical Name:1-{5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-2'-fluoro-3'-(hydroxyamino)-β-D-arabinofuranosyl}uracil
CAS No.:367491-83-6
Molecular Formula:C₂₅H₃₀FN₃O₅Si
Molecular Weight:499.614
Hs Code.:

Synonyms:1-{5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-2'-fluoro-3'-(hydroxyamino)-β-D-arabinofuranosyl}uracil

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Chemical Property of 1-{5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-2'-fluoro-3'-(hydroxyamino)-β-D-arabinofuranosyl}uracil

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Technology Process of 1-{5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-2'-fluoro-3'-(hydroxyamino)-β-D-arabinofuranosyl}uracil

There total 7 articles about 1-{5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-2'-fluoro-3'-(hydroxyamino)-β-D-arabinofuranosyl}uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 367491-82-5
1-{5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-2'-fluoro-3'-[hydroxy(methyl)amino]-β-D-arabinofuranosyl}uracil

: 367491-83-6
1-{5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-2'-fluoro-3'-(hydroxyamino)-β-D-arabinofuranosyl}uracil

Guidance literature:: 1-{5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-2'-fluoro-3'-[hydroxy(methyl)amino]-β-D-arabinofuranosyl}uracil; With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 0.5h;

With hydroxylamine hydrochloride; In methanol; at 50 ℃; for 1h;
DOI:10.1002/hlca.200490030

Reference yield:

: 5-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-5H-furan-2-one

: 367491-83-6
1-{5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-2'-fluoro-3'-(hydroxyamino)-β-D-arabinofuranosyl}uracil

Guidance literature:: Multi-step reaction with 7 steps

1.1: EtONa / ethanol / 0.17 h / 20 °C

1.2: 65 percent / ethanol / 5 h / Heating

2.1: 89 percent / imidazole / dimethylformamide / 20 °C

3.1: DIBAL [(tBu)2AlH] / CH₂Cl₂; hexane / 1 h / -78 °C

4.1: MsCl; Et₃N / Bu₃N / CH₂Cl₂ / -40 °C

4.2: 1 h / 20 °C

5.1: CHCl₃ / Heating

6.1: 99 percent / HF / acetonitrile; H₂O / 1 h / 20 °C

7.1: DDQ / CH₂Cl₂ / 0.5 h / 20 °C

7.2: 57 percent / NH₂OH*HCl / methanol / 1 h / 50 °C

With 1H-imidazole; hydrogen fluoride; sodium ethanolate; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tributyl-amine; In ethanol; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/hlca.200490030

Reference yield:

: 688036-02-4
5-O-[(tert-butyl)diphenylsilyl]-2,3-dideoxy-2-fluoro-3-[hydroxy(methyl)amino]-D-arabino-1,4-lactone

: 367491-83-6
1-{5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-2'-fluoro-3'-(hydroxyamino)-β-D-arabinofuranosyl}uracil

Guidance literature:: Multi-step reaction with 6 steps

1.1: 89 percent / imidazole / dimethylformamide / 20 °C

2.1: DIBAL [(tBu)2AlH] / CH₂Cl₂; hexane / 1 h / -78 °C

3.1: MsCl; Et₃N / Bu₃N / CH₂Cl₂ / -40 °C

3.2: 1 h / 20 °C

4.1: CHCl₃ / Heating

5.1: 99 percent / HF / acetonitrile; H₂O / 1 h / 20 °C

6.1: DDQ / CH₂Cl₂ / 0.5 h / 20 °C

6.2: 57 percent / NH₂OH*HCl / methanol / 1 h / 50 °C

With 1H-imidazole; hydrogen fluoride; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tributyl-amine; In hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/hlca.200490030