(E)-3-[4-(3-methylbut-2-enyloxy)styryl]-[ 1,2,4]triazolo[3,4-α]phthalazine

Base Information

Chemical Name:(E)-3-[4-(3-methylbut-2-enyloxy)styryl]-[ 1,2,4]triazolo[3,4-α]phthalazine
CAS No.:1268243-13-5
Molecular Formula:C₂₂H₂₀N₄O
Molecular Weight:356.427
Hs Code.:

Synonyms:(E)-3-[4-(3-methylbut-2-enyloxy)styryl]-[ 1,2,4]triazolo[3,4-α]phthalazine

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Chemical Property of (E)-3-[4-(3-methylbut-2-enyloxy)styryl]-[ 1,2,4]triazolo[3,4-α]phthalazine

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Technology Process of (E)-3-[4-(3-methylbut-2-enyloxy)styryl]-[ 1,2,4]triazolo[3,4-α]phthalazine

There total 5 articles about (E)-3-[4-(3-methylbut-2-enyloxy)styryl]-[ 1,2,4]triazolo[3,4-α]phthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: E-4-(2-([1,2,4]triazolo[3,4-a]phthalazin-3-yl)vinyl)phenol

: 870-63-3
prenyl bromide

: 1268243-13-5
(E)-3-[4-(3-methylbut-2-enyloxy)styryl]-[ 1,2,4]triazolo[3,4-α]phthalazine

Guidance literature:: E-4-(2-([1,2,4]triazolo[3,4-a]phthalazin-3-yl)vinyl)phenol; With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

prenyl bromide; In N,N-dimethyl-formamide; at 60 ℃; for 12h;
DOI:10.1002/cmdc.201600085

Reference yield: 52.0%

: (2E)-3-{4-[(3-methylbut-2-enyl)oxy]phenyl}prop-2-enoic acid

: 304-20-1
hydralazine hydrochloride

: 1268243-13-5
(E)-3-[4-(3-methylbut-2-enyloxy)styryl]-[ 1,2,4]triazolo[3,4-α]phthalazine

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; for 24h; Inert atmosphere; Reflux;
DOI:10.1021/jm101510d

Reference yield:

: 7400-08-0,50940-26-6
p-Coumaric Acid

: 1268243-13-5
(E)-3-[4-(3-methylbut-2-enyloxy)styryl]-[ 1,2,4]triazolo[3,4-α]phthalazine

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 24 h / Molecular sieve

2: potassium carbonate; potassium iodide / acetone / 20 h / Reflux

3: water; potassium carbonate / methanol / 3 h / Reflux

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 24 h / Inert atmosphere; Reflux

With sulfuric acid; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; In methanol; acetone; acetonitrile;
DOI:10.1021/jm101510d