(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-5-phenyl-1-(1H-1,2,4-triazol-1-yl)pentan-4-yn-2-ol

Base Information

Chemical Name:(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-5-phenyl-1-(1H-1,2,4-triazol-1-yl)pentan-4-yn-2-ol
CAS No.:1165800-95-2
Molecular Formula:C₂₀H₁₇F₂N₃O
Molecular Weight:353.371
Hs Code.:

Synonyms:(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-5-phenyl-1-(1H-1,2,4-triazol-1-yl)pentan-4-yn-2-ol

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Chemical Property of (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-5-phenyl-1-(1H-1,2,4-triazol-1-yl)pentan-4-yn-2-ol

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Technology Process of (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-5-phenyl-1-(1H-1,2,4-triazol-1-yl)pentan-4-yn-2-ol

There total 2 articles about (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-5-phenyl-1-(1H-1,2,4-triazol-1-yl)pentan-4-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

: 288-88-0
1,2,4-Triazole

: 1165800-94-1
(2R,3S)-1-chloro-2-(2,4-difluorophenyl)-3-methyl-5-phenylpent-4-yn-2-ol

: 1165800-95-2
(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-5-phenyl-1-(1H-1,2,4-triazol-1-yl)pentan-4-yn-2-ol

Guidance literature:: 1,2,4-Triazole; With sodium hydroxide; In dimethyl sulfoxide; at 70 ℃; for 0.5h;

(2R,3S)-1-chloro-2-(2,4-difluorophenyl)-3-methyl-5-phenylpent-4-yn-2-ol; In dimethyl sulfoxide; at 20 - 70 ℃;

With hydrogenchloride; water; In toluene;
DOI:10.1080/00397910802563420

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-4-pentyne-2-ol

: 1165800-95-2
(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-5-phenyl-1-(1H-1,2,4-triazol-1-yl)pentan-4-yn-2-ol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 12h; Inert atmosphere;