2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-methylbutyric acid ethyl ester

Base Information

Chemical Name:2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-methylbutyric acid ethyl ester
CAS No.:945483-85-2
Molecular Formula:C₂₂H₂₉N₂O₄P
Molecular Weight:416.457
Hs Code.:

Synonyms:2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-methylbutyric acid ethyl ester

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Chemical Property of 2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-methylbutyric acid ethyl ester

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Technology Process of 2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-methylbutyric acid ethyl ester

There total 3 articles about 2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-methylbutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 945483-93-2
C₁₅H₁₄NO₂P

: 17609-47-1
L-Valine ethyl ester hydrochloride

: 945483-85-2
2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-methylbutyric acid ethyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jo0705521

Reference yield:

: 1-bromo-1-(diphenylphosphinoyl)propan-2-one oxime

: 945483-85-2
2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-methylbutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / cooling

2: 90 percent / CH₂Cl₂ / 0.5 h / 20 °C

With triethylamine; In dichloromethane; 2: Michael addition;
DOI:10.1021/jo0705521

Reference yield:

: 201932-61-8
(E)-β-(N-hydroxyimino)propyldiphenylphosphine oxide

: 945483-85-2
2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-methylbutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methoxide / methanol / 1 h / Heating

1.2: 73 percent / bromine / methanol / 0 - 20 °C

2.1: triethylamine / CH₂Cl₂ / cooling

3.1: 90 percent / CH₂Cl₂ / 0.5 h / 20 °C

With sodium methylate; triethylamine; In methanol; dichloromethane; 3.1: Michael addition;
DOI:10.1021/jo0705521