(2R,4aR,6S,8aR)-8,8-Difluoro-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine

Base Information

• Chemical Name: (2R,4aR,6S,8aR)-8,8-Difluoro-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine
• CAS No.: 205592-61-6
• Molecular Formula: C₁₄H₁₆F₂O₄
• Molecular Weight: 286.275
• Mol file: 205592-61-6.mol

Synonyms:(2R,4aR,6S,8aR)-8,8-Difluoro-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine

Chemical Property of (2R,4aR,6S,8aR)-8,8-Difluoro-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4aR,6S,8aR)-8,8-Difluoro-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine

There total 1 articles about (2R,4aR,6S,8aR)-8,8-Difluoro-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methyl 4,6-O-(R)-benzylidene-2-deoxy-α-D-erythrohexopyranosid-3-ulose (63598-31-2) → (2R,4aR,6S,8aR)-8,8-Difluoro-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine (205592-61-6)

Guidance literature:

With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; for 2.5h; Ambient temperature;

DOI:10.1016/S0040-4020(98)00086-6

Reference yield:

(2R,4aR,6S,8aR)-8,8-Difluoro-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine (205592-61-6) → methyl 4,6-O-benzoyl-2,3-dideoxy-3,3-difluoro-α-D-erythro-hexopyranoside (205592-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / ethanol / 24 h / Ambient temperature

2: pyridine / 10 h

With hydrogenchloride; In pyridine; ethanol;

DOI:10.1016/S0040-4020(98)00086-6

Reference yield:

(2R,4aR,6S,8aR)-8,8-Difluoro-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine (205592-61-6) → C26H22F2O5Se

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / ethanol / 24 h / Ambient temperature

2: pyridine / 10 h

3: BF₃*OEt₂ / CH₂Cl₂ / 3 h / Heating

With hydrogenchloride; boron trifluoride diethyl etherate; In pyridine; ethanol; dichloromethane;

DOI:10.1016/S0040-4020(98)00086-6

upstream raw materials:

methyl 4,6-O-(R)-benzylidene-2-deoxy-α-D-erythrohexopyranosid-3-ulose

Downstream raw materials:

methyl 4,6-O-benzoyl-2,3-dideoxy-3,3-difluoro-α-D-erythro-hexopyranoside