(5-Chloro-thiophen-2-yl)-benzaldehyde

Base Information

Chemical Name:(5-Chloro-thiophen-2-yl)-benzaldehyde
CAS No.:223575-78-8
Molecular Formula:C₁₁H₇ClOS
Molecular Weight:222.695
Hs Code.:
ChEMBL ID:CHEMBL4590099
DSSTox Substance ID:DTXSID201297468

Synonyms:(5-Chloro-thiophen-2-yl)-benzaldehyde;223575-78-8;SCHEMBL2480109;CHEMBL4590099;ZVPWUNDTENJLOO-UHFFFAOYSA-N;DTXSID201297468;2-(5-Chloro-2-thienyl)benzaldehyde;AKOS018840454

Suppliers and Price of (5-Chloro-thiophen-2-yl)-benzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5-Chloro-thiophen-2-yl)-benzaldehyde

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:221.9906137
Heavy Atom Count:14
Complexity:210

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C=O)C2=CC=C(S2)Cl

Technology Process of (5-Chloro-thiophen-2-yl)-benzaldehyde

There total 1 articles about (5-Chloro-thiophen-2-yl)-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 2873-18-9
5-bromo-2-chlorothiophene

: 40138-16-7
2-formylbenzene boronic acid

: 223575-78-8
2-(5-chlorothien-2-yl)benzaldehyde

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; for 20h; Heating;
DOI:10.1016/j.tet.2008.07.021

Reference yield:

: 223575-78-8
2-(5-chlorothien-2-yl)benzaldehyde

: 1-[2-(aminooxy)ethyl]piperidine-3-carboxylic acid

: C₁₉H₂₁ClN₂O₃S

Guidance literature:: In aq. phosphate buffer; dimethyl sulfoxide; at 37 ℃; for 20h;
DOI:10.1016/j.ejmech.2020.112598

Reference yield:

: 223575-78-8
2-(5-chlorothien-2-yl)benzaldehyde

: 2-chloro-4-phenyl-6H-benzo[6,7]cyclohepta[1,2-b]thiophen-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere; Schlenk technique

1.2: 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: manganese(IV) oxide / dichloromethane / 3 h / 20 °C / Inert atmosphere; Schlenk technique

3.1: chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver hexafluoroantimonate / 1,2-dichloro-ethane / 2 h / 25 °C / Inert atmosphere; Schlenk technique

With manganese(IV) oxide; silver hexafluoroantimonate; n-butyllithium; chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1002/adsc.202001152