1,1-dimethylethyl [(1S)-2-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]-1-(hydroxymethyl)-2-oxoethyl]carbamate

Base Information

Chemical Name:1,1-dimethylethyl [(1S)-2-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]-1-(hydroxymethyl)-2-oxoethyl]carbamate
CAS No.:1258855-83-2
Molecular Formula:C₂₉H₃₃N₅O₆
Molecular Weight:547.611
Hs Code.:

1,1-dimethylethyl [(1S)-2-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]-1-(hydroxymethyl)-2-oxoethyl]carbamate

Synonyms:1,1-dimethylethyl [(1S)-2-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]-1-(hydroxymethyl)-2-oxoethyl]carbamate

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Chemical Property of 1,1-dimethylethyl [(1S)-2-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]-1-(hydroxymethyl)-2-oxoethyl]carbamate

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Technology Process of 1,1-dimethylethyl [(1S)-2-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]-1-(hydroxymethyl)-2-oxoethyl]carbamate

There total 7 articles about 1,1-dimethylethyl [(1S)-2-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]-1-(hydroxymethyl)-2-oxoethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258855-73-0
2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile mono-trifluoroacetate

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 1258855-83-2
1,1-dimethylethyl [(1S)-2-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]-1-(hydroxymethyl)-2-oxoethyl]carbamate

Guidance literature:: With N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1258855-83-2
1,1-dimethylethyl [(1S)-2-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]-1-(hydroxymethyl)-2-oxoethyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C

2: pyridine / toluene / 3 h / 120 °C / Reflux

3: dichloromethane / 0 - 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 20 °C

With N-ethylmorpholine;; pyridine; oxalyl dichloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1072948-37-8
3-cyano-4-[(1-methylethyl)oxy]benzoyl chloride

: 1258855-83-2
1,1-dimethylethyl [(1S)-2-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]-1-(hydroxymethyl)-2-oxoethyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / toluene / 3 h / 120 °C / Reflux

2: dichloromethane / 0 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 20 °C

With N-ethylmorpholine;; pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; toluene;