1-(3-(4-(4-acetylpiperazin-1-yl)-4-oxobutoxy)phenyl)-3-adamantan-1-ylurea

Base Information

Chemical Name:1-(3-(4-(4-acetylpiperazin-1-yl)-4-oxobutoxy)phenyl)-3-adamantan-1-ylurea
CAS No.:1254951-44-4
Molecular Formula:C₂₇H₃₈N₄O₄
Molecular Weight:482.623
Hs Code.:

Synonyms:1-(3-(4-(4-acetylpiperazin-1-yl)-4-oxobutoxy)phenyl)-3-adamantan-1-ylurea

Suppliers and Price of 1-(3-(4-(4-acetylpiperazin-1-yl)-4-oxobutoxy)phenyl)-3-adamantan-1-ylurea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(3-(4-(4-acetylpiperazin-1-yl)-4-oxobutoxy)phenyl)-3-adamantan-1-ylurea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(3-(4-(4-acetylpiperazin-1-yl)-4-oxobutoxy)phenyl)-3-adamantan-1-ylurea

There total 6 articles about 1-(3-(4-(4-acetylpiperazin-1-yl)-4-oxobutoxy)phenyl)-3-adamantan-1-ylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1254951-43-3
1-adamantan-1-yl-3-(3-(4-oxo-4-(piperazin-1-yl)butoxy)phenyl)urea

: 108-24-7
acetic anhydride

: 1254951-44-4
1-(3-(4-(4-acetylpiperazin-1-yl)-4-oxobutoxy)phenyl)-3-adamantan-1-ylurea

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm101087u

Reference yield:

: 1254951-41-1
tert-butyl 4-(4-(3-aminophenoxy)butanoyl)piperazine-1-carboxylate

: 1254951-44-4
1-(3-(4-(4-acetylpiperazin-1-yl)-4-oxobutoxy)phenyl)-3-adamantan-1-ylurea

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 0 °C

2: trifluoroacetic acid / dichloromethane / 10 h / 0 - 20 °C

3: triethylamine / dichloromethane / 2 h

With triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 30297-87-1
4-(3-nitrophenoxy)butanoic acid

: 1254951-44-4
1-(3-(4-(4-acetylpiperazin-1-yl)-4-oxobutoxy)phenyl)-3-adamantan-1-ylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.33 h / 0 °C

1.2: 5 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol

3.1: dichloromethane / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 10 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 2 h

With 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;