2-(4-fluorophenyl)-3-hydroxy-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-propanamide

Base Information

Chemical Name:2-(4-fluorophenyl)-3-hydroxy-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-propanamide
CAS No.:1443763-69-6
Molecular Formula:C₃₀H₂₅F₄N₅O₅S
Molecular Weight:643.619
Hs Code.:

Synonyms:2-(4-fluorophenyl)-3-hydroxy-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-propanamide

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Chemical Property of 2-(4-fluorophenyl)-3-hydroxy-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-propanamide

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Technology Process of 2-(4-fluorophenyl)-3-hydroxy-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-propanamide

There total 13 articles about 2-(4-fluorophenyl)-3-hydroxy-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34837-84-8
4-fluorobenzeneacetic acid methyl ester

: 1443763-69-6
2-(4-fluorophenyl)-3-hydroxy-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium methylate / dimethyl sulfoxide / 16 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C

3: sodium hydroxide; water / isopropyl alcohol / 0.5 h / 60 °C

4: potassium carbonate; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; water; sodium methylate; potassium carbonate; HATU; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1443764-07-5
3-{[tert-butyl(diphenyl)silyl]oxy}-2-(4-fluorophenyl)-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide

: 1443763-69-6
2-(4-fluorophenyl)-3-hydroxy-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-propanamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1443764-05-3
methyl 3-{[tert-butyl(diphenyl)silyl]oxy}-2-(4-fluorophenyl)propanoate

: 1443763-69-6
2-(4-fluorophenyl)-3-hydroxy-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / isopropyl alcohol / 0.5 h / 60 °C

2: potassium carbonate; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; water; potassium carbonate; HATU; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;